BAIT

MIG1

CAT4, SSN1, TDS22, transcription factor MIG1, L000001110, YGL035C
Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion; activated in stochastic pulses of nuclear localization, shuttling between cytosol and nucleus depending on external glucose levels and its phosphorylation state
Saccharomyces cerevisiae (S288c)
PREY

RPI1

L000001697, YIL119C
Transcription factor, allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF
GO Process (3)
GO Function (1)
GO Component (1)
Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Critical role of RPI1 in the stress tolerance of yeast during ethanolic fermentation.

Puria R, Mannan MA, Chopra-Dewasthaly R, Ganesan K

Stress tolerance of yeast Saccharomyces cerevisiae during ethanolic fermentation is poorly understood due to the lack of genetic screens and conventional plate assays for studying this phenotype. We screened a genomic expression library of yeast to identify gene(s) that, upon overexpression, would prolong the survival of yeast cells during fermentation, with the view to understand the stress response better and ... [more]

FEMS Yeast Res. Dec. 01, 2009; 9(8);1161-71 [Pubmed: 19678848]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: fermentative growth (APO:0000308)

Additional Notes

  • Overexpression of RPI1 partially rescues growth defects of MIG1 mutants in fermentative conditions

Curated By

  • BioGRID