BAIT

PARP

BEST:LD21673, CG17685, CG17696, CG17718, CG40411, D.PARP, Dm.pARTa, Dmel\CG40411, LD21673.3prime, PARP-1, PARP1, dPARP, dmparp, Dmel_CG40411
Poly-(ADP-ribose) polymerase
Drosophila melanogaster
PREY

HIS2B:CG17949

CG17949, Dmel\CG17949, Dmel_CG17949
CG17949 gene product from transcript CG17949-RA
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Drosophila melanogaster

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity.

Pinnola A, Naumova N, Shah M, Tulin AV

Poly(ADP-ribose) polymerase 1 protein (PARP1) mediates chromatin loosening and activates the transcription of inducible genes, but the mechanism of PARP1 regulation in chromatin is poorly understood. We have found that PARP1 interaction with chromatin is dynamic and that PARP1 is exchanged continuously between chromatin and nucleoplasm, as well as between chromatin domains. Specifically, the PARP1 protein preferentially interacts with nucleosomal ... [more]

J. Biol. Chem. Nov. 02, 2007; 282(44);32511-9 [Pubmed: 17827147]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
PARP HIS2B:CG17949
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Low-BioGRID
-
HIS2B:CG17949 PARP
Reconstituted Complex
Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Low-BioGRID
-

Curated By

  • BioGRID