BAIT
SMAD1
BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1
SMAD family member 1
GO Process (10)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, ISS, TAS]
- SMAD protein complex assembly [IDA]
- cellular response to BMP stimulus [ISS]
- embryonic pattern specification [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IC, IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [ISS]
- primary miRNA processing [TAS]
- signal transduction [NAS]
- transforming growth factor beta receptor signaling pathway [NAS]
Gene Ontology Molecular Function- I-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- co-SMAD binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- receptor signaling protein activity [NAS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [TAS]
- I-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- co-SMAD binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- receptor signaling protein activity [NAS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
OAZ1
AZI, OAZ
ornithine decarboxylase antizyme 1
GO Process (6)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- cellular nitrogen compound metabolic process [TAS]
- negative regulation of catalytic activity [IDA, ISS, TAS]
- positive regulation of intracellular protein transport [ISS]
- positive regulation of protein catabolic process [IDA, ISS]
- regulation of cellular amino acid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Proteasomal degradation of Smad1 induced by bone morphogenetic proteins.
The bone morphogenetic proteins (BMPs) regulate early embryogenesis and morphogenesis of multiple organs, such as bone, kidney, limbs, and muscle. Smad1 is one of the key signal transducers of BMPs and is responsible for transducing receptor activation signals from the cytoplasm to the nucleus, where Smad1 serves as a transcriptional regulator of various BMP-responsive genes. Based upon the ability of ... [more]
J. Biol. Chem. Dec. 07, 2001; 276(49);46533-43 [Pubmed: 11571290]
Throughput
- Low Throughput
Curated By
- BioGRID