BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1
SMAD family member 1
Homo sapiens


Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.


Proteasomal degradation of Smad1 induced by bone morphogenetic proteins.

Gruendler C, Lin Y, Farley J, Wang T

The bone morphogenetic proteins (BMPs) regulate early embryogenesis and morphogenesis of multiple organs, such as bone, kidney, limbs, and muscle. Smad1 is one of the key signal transducers of BMPs and is responsible for transducing receptor activation signals from the cytoplasm to the nucleus, where Smad1 serves as a transcriptional regulator of various BMP-responsive genes. Based upon the ability of ... [more]

J. Biol. Chem. Dec. 07, 2001; 276(49);46533-43 [Pubmed: 11571290]


  • Low Throughput

Curated By

  • BioGRID