BAIT

TOPORS

LUN, P53BP3, RP31, TP53BPL, RP11-205M20.5
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Homo sapiens
PREY

SAFB2

scaffold attachment factor B2
GO Process (0)
GO Function (3)
GO Component (3)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins.

Pungaliya P, Kulkarni D, Park HJ, Marshall H, Zheng H, Lackland H, Saleem A, Rubin EH

TOPORS is the first example of a protein with both ubiquitin and SUMO-1 E3 ligase activity and has been implicated as a tumor suppressor in several different malignancies. To gain insight into the cellular role of TOPORS, a proteomic screen was performed to identify candidate sumoylation substrates. The results indicate that many of the putative substrates are involved in chromatin ... [more]

J. Proteome Res. Oct. 01, 2007; 6(10);3918-23 [Pubmed: 17803295]

Throughput

  • Low Throughput

Curated By

  • BioGRID