BAIT
SFRP2
AI851596, Sdf5
secreted frizzled-related protein 2
GO Process (60)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IGI]
- anterior/posterior pattern specification [IGI]
- apoptotic process [IMP]
- bone morphogenesis [IMP]
- cardiac left ventricle morphogenesis [ISO]
- cartilage development [IMP]
- cellular response to X-ray [IDA]
- cellular response to extracellular stimulus [IDA]
- chondrocyte development [IMP]
- collagen fibril organization [IMP]
- convergent extension involved in axis elongation [IGI]
- development of primary male sexual characteristics [IGI]
- digestive tract morphogenesis [IGI]
- embryonic digit morphogenesis [IMP]
- hematopoietic stem cell proliferation [IDA]
- male gonad development [IGI]
- negative regulation of BMP signaling pathway [IDA, IGI]
- negative regulation of JUN kinase activity [IGI]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, ISO]
- negative regulation of cardiac muscle cell apoptotic process [IDA]
- negative regulation of cell growth [ISO]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of dermatome development [IDA]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of mesodermal cell fate specification [IGI]
- negative regulation of peptidyl-tyrosine phosphorylation [IDA]
- negative regulation of planar cell polarity pathway involved in axis elongation [IGI]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [IGI]
- neural tube development [IGI]
- outflow tract morphogenesis [ISO]
- patterning of blood vessels [IDA]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of angiogenesis [IDA]
- positive regulation of apoptotic process [ISO]
- positive regulation of canonical Wnt signaling pathway [IDA, IGI]
- positive regulation of catenin import into nucleus [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of endopeptidase activity [IDA]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of osteoblast differentiation [IGI]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of receptor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- post-anal tail morphogenesis [IMP]
- regulation of Wnt signaling pathway [IDA]
- regulation of apoptotic process [IMP]
- regulation of cell proliferation [IMP]
- regulation of establishment of planar polarity [IGI]
- regulation of stem cell division [IDA]
- response to drug [IDA]
- signal transduction [IDA]
- somitogenesis [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
WG
Br, CG4889, DWint-1, DWnt-1, Dint-1, Dm Wg, Dm-1, Dmel\CG4889, Gla, I, Sp, WNT, Wnt-1, Wnt/Wg, Wnt1, dWnt, fg, int-1, l(2)02657, l(2)rO727, l(2)wg, spd, wgl, Dmel_CG4889
wingless
GO Process (85)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- Malpighian tubule bud morphogenesis [IMP]
- Malpighian tubule tip cell differentiation [IMP]
- Wnt signaling pathway [NAS]
- Wnt signaling pathway, calcium modulating pathway [IDA, IGI]
- actin filament bundle assembly [IMP]
- anterior head segmentation [TAS]
- anterior/posterior axis specification, embryo [NAS, TAS]
- anterior/posterior pattern specification, imaginal disc [IMP]
- axis specification [IBA]
- branch fusion, open tracheal system [IMP]
- branching morphogenesis of an epithelial tube [IMP]
- canonical Wnt signaling pathway [IDA, IGI]
- cardioblast differentiation [IMP]
- compound eye development [TAS]
- compound eye morphogenesis [IMP]
- cuticle pattern formation [IMP]
- determination of genital disc primordium [IMP]
- dorsal closure [IMP]
- dorsal closure, elongation of leading edge cells [IMP]
- dorsal/ventral pattern formation, imaginal disc [IMP, TAS]
- ectoderm development [IMP]
- epidermis development [IMP]
- epithelial cell proliferation involved in Malpighian tubule morphogenesis [IMP]
- epithelial cell type specification, open tracheal system [IMP]
- filopodium assembly [IMP]
- genital disc anterior/posterior pattern formation [IEP]
- genital disc development [TAS]
- genital disc sexually dimorphic development [IMP]
- heart development [IMP]
- heart formation [IMP]
- hindgut morphogenesis [IMP]
- imaginal disc development [IMP]
- imaginal disc growth [TAS]
- imaginal disc pattern formation [TAS]
- imaginal disc-derived wing morphogenesis [IMP]
- instar larval development [TAS]
- labial disc development [IMP]
- lamellipodium assembly [IMP]
- larval lymph gland hemopoiesis [IMP]
- larval visceral muscle development [IMP]
- leg disc proximal/distal pattern formation [NAS, TAS]
- long-term memory [IMP]
- lymph gland crystal cell differentiation [IMP]
- lymph gland development [IMP]
- mesoderm development [IMP]
- mesoderm morphogenesis [IMP]
- midbrain-hindbrain boundary development [IBA]
- negative regulation of DNA endoreduplication [IMP]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell fate specification [IMP]
- negative regulation of fat cell differentiation [IBA]
- negative regulation of heart induction by canonical Wnt signaling pathway [IMP]
- negative regulation of hemocyte differentiation [IMP]
- negative regulation of phosphorylation [NAS]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- negative regulation of transcription, DNA-templated [IMP]
- neuroblast development [IMP]
- ommatidial rotation [TAS]
- ovarian follicle cell development [IMP]
- pericardial nephrocyte differentiation [IMP]
- positive regulation of cell proliferation [IGI, IMP]
- positive regulation of compound eye retinal cell programmed cell death [IMP]
- positive regulation of crystal cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IBA]
- posterior Malpighian tubule development [IMP]
- posterior head segmentation [TAS]
- proboscis development [IMP]
- regulation of cell proliferation [NAS]
- regulation of compound eye pigmentation [IMP]
- regulation of imaginal disc-derived wing size [IMP]
- regulation of mitotic cell cycle [TAS]
- regulation of stem cell proliferation [IMP]
- regulation of transcription, DNA-templated [IMP]
- segment polarity determination [IMP, TAS]
- sensory organ development [TAS]
- somatic stem cell maintenance [IBA]
- spiracle morphogenesis, open tracheal system [IMP]
- synapse organization [IMP]
- synaptic growth at neuromuscular junction [IMP]
- trunk segmentation [TAS]
- ventral cord development [TAS]
- ventral midline development [IMP]
- wing cell fate specification [IMP]
- wing disc development [IGI]
- wing disc dorsal/ventral pattern formation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.
This paper describes the identification of a new family of mammalian genes that encode secreted proteins containing homology to the cysteine-rich ligand-binding domain found in the frizzled family of transmembrane receptors. The secreted frizzled-related proteins (sFRPs) are approximately 30 kDa in size, and each contains a putative signal sequence, a frizzled-like cysteine-rich domain, and a conserved hydrophilic carboxy-terminal domain. The ... [more]
Proc. Natl. Acad. Sci. U.S.A. Apr. 01, 1997; 94(7);2859-63 [Pubmed: 9096311]
Throughput
- Low Throughput
Additional Notes
- Drosophila Wingless labels mouse sFRP-2 and -3 expressed on the surface of human 293 cells.
Curated By
- BioGRID