BAIT
SFRP2
AI851596, Sdf5
secreted frizzled-related protein 2
GO Process (60)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IGI]
- anterior/posterior pattern specification [IGI]
- apoptotic process [IMP]
- bone morphogenesis [IMP]
- cardiac left ventricle morphogenesis [ISO]
- cartilage development [IMP]
- cellular response to X-ray [IDA]
- cellular response to extracellular stimulus [IDA]
- chondrocyte development [IMP]
- collagen fibril organization [IMP]
- convergent extension involved in axis elongation [IGI]
- development of primary male sexual characteristics [IGI]
- digestive tract morphogenesis [IGI]
- embryonic digit morphogenesis [IMP]
- hematopoietic stem cell proliferation [IDA]
- male gonad development [IGI]
- negative regulation of BMP signaling pathway [IDA, IGI]
- negative regulation of JUN kinase activity [IGI]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, ISO]
- negative regulation of cardiac muscle cell apoptotic process [IDA]
- negative regulation of cell growth [ISO]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of dermatome development [IDA]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of mesodermal cell fate specification [IGI]
- negative regulation of peptidyl-tyrosine phosphorylation [IDA]
- negative regulation of planar cell polarity pathway involved in axis elongation [IGI]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [IGI]
- neural tube development [IGI]
- outflow tract morphogenesis [ISO]
- patterning of blood vessels [IDA]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of angiogenesis [IDA]
- positive regulation of apoptotic process [ISO]
- positive regulation of canonical Wnt signaling pathway [IDA, IGI]
- positive regulation of catenin import into nucleus [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of endopeptidase activity [IDA]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of osteoblast differentiation [IGI]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of receptor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- post-anal tail morphogenesis [IMP]
- regulation of Wnt signaling pathway [IDA]
- regulation of apoptotic process [IMP]
- regulation of cell proliferation [IMP]
- regulation of establishment of planar polarity [IGI]
- regulation of stem cell division [IDA]
- response to drug [IDA]
- signal transduction [IDA]
- somitogenesis [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
WG
Br, CG4889, DWint-1, DWnt-1, Dint-1, Dm Wg, Dm-1, Dmel\CG4889, Gla, I, Sp, WNT, Wnt-1, Wnt/Wg, Wnt1, dWnt, fg, int-1, l(2)02657, l(2)rO727, l(2)wg, spd, wgl, Dmel_CG4889
wingless
GO Process (85)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- Malpighian tubule bud morphogenesis [IMP]
- Malpighian tubule tip cell differentiation [IMP]
- Wnt signaling pathway [NAS]
- Wnt signaling pathway, calcium modulating pathway [IDA, IGI]
- actin filament bundle assembly [IMP]
- anterior head segmentation [TAS]
- anterior/posterior axis specification, embryo [NAS, TAS]
- anterior/posterior pattern specification, imaginal disc [IMP]
- axis specification [IBA]
- branch fusion, open tracheal system [IMP]
- branching morphogenesis of an epithelial tube [IMP]
- canonical Wnt signaling pathway [IDA, IGI]
- cardioblast differentiation [IMP]
- compound eye development [TAS]
- compound eye morphogenesis [IMP]
- cuticle pattern formation [IMP]
- determination of genital disc primordium [IMP]
- dorsal closure [IMP]
- dorsal closure, elongation of leading edge cells [IMP]
- dorsal/ventral pattern formation, imaginal disc [IMP, TAS]
- ectoderm development [IMP]
- epidermis development [IMP]
- epithelial cell proliferation involved in Malpighian tubule morphogenesis [IMP]
- epithelial cell type specification, open tracheal system [IMP]
- filopodium assembly [IMP]
- genital disc anterior/posterior pattern formation [IEP]
- genital disc development [TAS]
- genital disc sexually dimorphic development [IMP]
- heart development [IMP]
- heart formation [IMP]
- hindgut morphogenesis [IMP]
- imaginal disc development [IMP]
- imaginal disc growth [TAS]
- imaginal disc pattern formation [TAS]
- imaginal disc-derived wing morphogenesis [IMP]
- instar larval development [TAS]
- labial disc development [IMP]
- lamellipodium assembly [IMP]
- larval lymph gland hemopoiesis [IMP]
- larval visceral muscle development [IMP]
- leg disc proximal/distal pattern formation [NAS, TAS]
- long-term memory [IMP]
- lymph gland crystal cell differentiation [IMP]
- lymph gland development [IMP]
- mesoderm development [IMP]
- mesoderm morphogenesis [IMP]
- midbrain-hindbrain boundary development [IBA]
- negative regulation of DNA endoreduplication [IMP]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell fate specification [IMP]
- negative regulation of fat cell differentiation [IBA]
- negative regulation of heart induction by canonical Wnt signaling pathway [IMP]
- negative regulation of hemocyte differentiation [IMP]
- negative regulation of phosphorylation [NAS]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- negative regulation of transcription, DNA-templated [IMP]
- neuroblast development [IMP]
- ommatidial rotation [TAS]
- ovarian follicle cell development [IMP]
- pericardial nephrocyte differentiation [IMP]
- positive regulation of cell proliferation [IGI, IMP]
- positive regulation of compound eye retinal cell programmed cell death [IMP]
- positive regulation of crystal cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IBA]
- posterior Malpighian tubule development [IMP]
- posterior head segmentation [TAS]
- proboscis development [IMP]
- regulation of cell proliferation [NAS]
- regulation of compound eye pigmentation [IMP]
- regulation of imaginal disc-derived wing size [IMP]
- regulation of mitotic cell cycle [TAS]
- regulation of stem cell proliferation [IMP]
- regulation of transcription, DNA-templated [IMP]
- segment polarity determination [IMP, TAS]
- sensory organ development [TAS]
- somatic stem cell maintenance [IBA]
- spiracle morphogenesis, open tracheal system [IMP]
- synapse organization [IMP]
- synaptic growth at neuromuscular junction [IMP]
- trunk segmentation [TAS]
- ventral cord development [TAS]
- ventral midline development [IMP]
- wing cell fate specification [IMP]
- wing disc development [IGI]
- wing disc dorsal/ventral pattern formation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.
This paper describes the identification of a new family of mammalian genes that encode secreted proteins containing homology to the cysteine-rich ligand-binding domain found in the frizzled family of transmembrane receptors. The secreted frizzled-related proteins (sFRPs) are approximately 30 kDa in size, and each contains a putative signal sequence, a frizzled-like cysteine-rich domain, and a conserved hydrophilic carboxy-terminal domain. The ... [more]
Proc. Natl. Acad. Sci. U.S.A. Apr. 01, 1997; 94(7);2859-63 [Pubmed: 9096311]
Throughput
- Low Throughput
Additional Notes
- Drosophila Wingless labels mouse sFRP-2 and -3 expressed on the surface of human 293 cells.
Curated By
- BioGRID