ROR2
Gene Ontology Biological Process
- JNK cascade [IDA]
- Wnt signaling pathway, calcium modulating pathway [IPI]
- Wnt signaling pathway, planar cell polarity pathway [IMP]
- cartilage condensation [IMP]
- cell differentiation [IMP]
- embryonic genitalia morphogenesis [IMP]
- inner ear morphogenesis [IMP]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of cell proliferation [ISO]
- peptidyl-tyrosine phosphorylation [TAS]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell migration [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
- skeletal system development [IMP]
- somitogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FZD2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [IDA]
- Wnt signaling pathway, calcium modulating pathway [IDA]
- canonical Wnt signaling pathway [IBA, ISO]
- cell activation [IEP]
- cell-cell signaling [ISO]
- cellular response to growth factor stimulus [IEP]
- cellular response to peptide hormone stimulus [IEP]
- cellular response to vitamin D [IEP]
- cochlea morphogenesis [ISO]
- epithelial cell differentiation [ISO]
- hard palate development [ISO]
- inner ear receptor cell development [ISO]
- membranous septum morphogenesis [ISO]
- muscular septum morphogenesis [ISO]
- outflow tract morphogenesis [ISO]
- planar cell polarity pathway involved in neural tube closure [ISO]
- positive regulation of cGMP metabolic process [ISO]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- sensory perception of smell [ISO]
- signal transduction [ISO]
- ventricular septum morphogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.
Ror2 is an orphan receptor, belonging to the Ror family of receptor tyrosine kinases. Although Ror2 has been shown to play crucial roles in developmental morphogenesis, the precise signalling events that Ror2 mediates remain elusive. Since Ror2 possesses an extracellular cysteine-rich domain (CRD) that resembles the Wnt-binding sites of the Frizzled (Fz) proteins, it is conceivable that Ror2 interacts with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID