SFRP1
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IGI]
- Wnt signaling pathway, planar cell polarity pathway [IDA]
- actin cytoskeleton organization [ISO]
- anterior/posterior pattern specification [IGI]
- bone trabecula formation [IMP]
- canonical Wnt signaling pathway [ISO]
- cellular response to X-ray [IDA]
- cellular response to estrogen stimulus [IDA, ISO]
- cellular response to fibroblast growth factor stimulus [ISO]
- cellular response to growth factor stimulus [ISO]
- cellular response to heparin [ISO]
- cellular response to tumor necrosis factor [ISO]
- convergent extension involved in somitogenesis [IGI]
- development of primary male sexual characteristics [IGI]
- digestive tract morphogenesis [IGI]
- dorsal/ventral axis specification [ISO]
- female gonad development [IGI]
- hematopoietic progenitor cell differentiation [ISO]
- hematopoietic stem cell differentiation [ISO]
- hemopoiesis [IMP]
- male gonad development [IGI]
- negative regulation of B cell differentiation [IMP, ISO]
- negative regulation of BMP signaling pathway [IGI]
- negative regulation of JUN kinase activity [IGI]
- negative regulation of Wnt signaling pathway [IGI, ISO]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [ISO]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of bone remodeling [ISO]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, ISO]
- negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of fibroblast apoptotic process [ISO]
- negative regulation of fibroblast proliferation [ISO]
- negative regulation of gene expression [IMP, ISO]
- negative regulation of insulin secretion [ISO]
- negative regulation of ossification [IMP, ISO]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of osteoblast proliferation [IMP, ISO]
- negative regulation of osteoclast differentiation [IMP, ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of planar cell polarity pathway involved in axis elongation [IGI]
- negative regulation of transcription, DNA-templated [ISO]
- neural crest cell fate commitment [IMP]
- neural tube closure [IGI]
- neural tube development [IGI]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of Wnt signaling pathway [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of fibroblast apoptotic process [ISO]
- positive regulation of non-canonical Wnt signaling pathway [ISO]
- positive regulation of smoothened signaling pathway [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [IMP]
- proteolysis [ISO]
- regulation of branching involved in prostate gland morphogenesis [IMP]
- regulation of cell cycle process [ISO]
- regulation of establishment of planar polarity [IGI]
- regulation of ossification [ISO]
- response to drug [IDA, ISO]
- response to organic cyclic compound [ISO]
- somatic stem cell maintenance [IMP]
- somitogenesis [IGI]
- substrate adhesion-dependent cell spreading [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WNT8A
Gene Ontology Biological Process
- Wnt signaling pathway [IBA]
- cell fate commitment [IBA]
- cell morphogenesis [IMP]
- endoderm development [IMP]
- establishment of organ orientation [IMP]
- neuron differentiation [IBA]
- palate development [ISO]
- polarity specification of anterior/posterior axis [IMP]
- polarity specification of proximal/distal axis [IMP]
- regionalization [IMP]
- regulation of protein localization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart morphogenesis.
The Wnt genes encode a large family of secreted proteins that play a key role in embryonic development and tissue differentiation in many species (Rijsewijk et al., 1987; Nusse and Varmus, 1992). Genetic and biochemical studies have suggested that the frizzled proteins are cell surface receptors for Wnts (Vinson et al., 1989; Chan et al. , 1992; Bhanot et al., ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WNT8A SFRP1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID