BAIT
SFRP1
2210415K03Rik, AW011917, AW107218, AW742929, sFRP-1
secreted frizzled-related protein 1
GO Process (75)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IGI]
- Wnt signaling pathway, planar cell polarity pathway [IDA]
- actin cytoskeleton organization [ISO]
- anterior/posterior pattern specification [IGI]
- bone trabecula formation [IMP]
- canonical Wnt signaling pathway [ISO]
- cellular response to X-ray [IDA]
- cellular response to estrogen stimulus [IDA, ISO]
- cellular response to fibroblast growth factor stimulus [ISO]
- cellular response to growth factor stimulus [ISO]
- cellular response to heparin [ISO]
- cellular response to tumor necrosis factor [ISO]
- convergent extension involved in somitogenesis [IGI]
- development of primary male sexual characteristics [IGI]
- digestive tract morphogenesis [IGI]
- dorsal/ventral axis specification [ISO]
- female gonad development [IGI]
- hematopoietic progenitor cell differentiation [ISO]
- hematopoietic stem cell differentiation [ISO]
- hemopoiesis [IMP]
- male gonad development [IGI]
- negative regulation of B cell differentiation [IMP, ISO]
- negative regulation of BMP signaling pathway [IGI]
- negative regulation of JUN kinase activity [IGI]
- negative regulation of Wnt signaling pathway [IGI, ISO]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [ISO]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of bone remodeling [ISO]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, ISO]
- negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of fibroblast apoptotic process [ISO]
- negative regulation of fibroblast proliferation [ISO]
- negative regulation of gene expression [IMP, ISO]
- negative regulation of insulin secretion [ISO]
- negative regulation of ossification [IMP, ISO]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of osteoblast proliferation [IMP, ISO]
- negative regulation of osteoclast differentiation [IMP, ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of planar cell polarity pathway involved in axis elongation [IGI]
- negative regulation of transcription, DNA-templated [ISO]
- neural crest cell fate commitment [IMP]
- neural tube closure [IGI]
- neural tube development [IGI]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of Wnt signaling pathway [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of fibroblast apoptotic process [ISO]
- positive regulation of non-canonical Wnt signaling pathway [ISO]
- positive regulation of smoothened signaling pathway [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [IMP]
- proteolysis [ISO]
- regulation of branching involved in prostate gland morphogenesis [IMP]
- regulation of cell cycle process [ISO]
- regulation of establishment of planar polarity [IGI]
- regulation of ossification [ISO]
- response to drug [IDA, ISO]
- response to organic cyclic compound [ISO]
- somatic stem cell maintenance [IMP]
- somitogenesis [IGI]
- substrate adhesion-dependent cell spreading [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
WNT8A
Stra11, Wnt-8A, Wnt-8D, Wnt8d
wingless-type MMTV integration site family, member 8A
GO Process (11)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- Wnt signaling pathway [IBA]
- cell fate commitment [IBA]
- cell morphogenesis [IMP]
- endoderm development [IMP]
- establishment of organ orientation [IMP]
- neuron differentiation [IBA]
- palate development [ISO]
- polarity specification of anterior/posterior axis [IMP]
- polarity specification of proximal/distal axis [IMP]
- regionalization [IMP]
- regulation of protein localization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart morphogenesis.
The Wnt genes encode a large family of secreted proteins that play a key role in embryonic development and tissue differentiation in many species (Rijsewijk et al., 1987; Nusse and Varmus, 1992). Genetic and biochemical studies have suggested that the frizzled proteins are cell surface receptors for Wnts (Vinson et al., 1989; Chan et al. , 1992; Bhanot et al., ... [more]
Mech. Dev. Feb. 01, 2000; 90(2);263-7 [Pubmed: 10640709]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WNT8A SFRP1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID