BCO3, LCA2, RP20, mRPE65, rd12, sRPE65
retinal pigment epithelium-specific protein 65kDa
Homo sapiens


solute carrier family 27 (fatty acid transporter), member 1
GO Process (0)
GO Function (0)
GO Component (0)
Sus scrofa


Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.


FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase.

Guignard TJ, Jin M, Pequignot MO, Li S, Chassigneux Y, Chekroud K, Guillou L, Richard E, Hamel CP, Brabet P

The isomerization of all-trans retinol (vitamin A) to 11-cis retinol in the retinal pigment epithelium (RPE) is a key step in the visual process for the regeneration of the visual pigment chromophore, 11-cis retinal. LRAT and RPE65 are recognized as the minimal isomerase catalytic components. However, regulators of this rate-limiting step are not fully identified and could account for the ... [more]

J. Biol. Chem. Jun. 11, 2010; 285(24);18759-68 [Pubmed: 20356843]


  • Low Throughput

Curated By

  • BioGRID