FUN30
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IMP]
- DNA double-strand break processing [IMP]
- chromatin silencing at rDNA [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- heterochromatin assembly involved in chromatin silencing [IMP]
- heterochromatin maintenance involved in chromatin silencing [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ISW1
Gene Ontology Biological Process
- DNA-templated transcription, elongation [IDA, IMP]
- chromatin organization involved in regulation of transcription [IMP]
- chromatin remodeling [IGI, IMP, IPI]
- heterochromatin maintenance involved in chromatin silencing [IGI, IMP]
- negative regulation of histone exchange [IMP]
- nucleosome positioning [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of chromatin organization [IMP]
- regulation of transcriptional start site selection at RNA polymerase II promoter [IGI]
- termination of RNA polymerase I transcription [IGI]
- termination of RNA polymerase II transcription [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Roles of chromatin remodeling factors in the formation and maintenance of heterochromatin structure.
Heterochromatin consists of highly ordered nucleosomes with characteristic histone modifications. There is evidence implicating chromatin remodeling proteins in heterochromatin formation, but their exact roles are not clear. We demonstrate in Saccharomyces cerevisiae, the Fun30p and Isw1p chromatin remodeling factors are similarly required for transcriptional silencing at the HML locus, but they differentially contribute to the structure and stability of HML ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: silencing (APO:0000046)
Additional Notes
- double mutants show a slight decrease in silencing of HML
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ISW1 FUN30 | Affinity Capture-RNA Affinity Capture-RNA An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis. | High | - | BioGRID | 2336103 |
Curated By
- BioGRID