BAIT

GCD11

SUI4, translation initiation factor eIF2 subunit gamma, L000000677, YER025W
Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID)
Saccharomyces cerevisiae (S288c)
PREY

SUI1

MOF2, RFR1, translation initiation factor eIF1, L000002177, YNL244C
Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Translation initiation factor 2gamma mutant alters start codon selection independent of Met-tRNA binding.

Alone PV, Cao C, Dever TE

Selection of the AUG start codon for translation in eukaryotes is governed by codon-anticodon interactions between the initiator Met-tRNA(i)(Met) and the mRNA. Translation initiation factor 2 (eIF2) binds Met-tRNA(i)(Met) to the 40S ribosomal subunit, and previous studies identified Sui(-) mutations in eIF2 that enhanced initiation from a noncanonical UUG codon, presumably by impairing Met-tRNA(i)(Met) binding. Consistently, an eIF2gamma-N135D GTP-binding domain ... [more]

Mol. Cell. Biol. Nov. 01, 2008; 28(22);6877-88 [Pubmed: 18794367]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)

Curated By

  • BioGRID