PORCN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WNT1
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- Spemann organizer formation [IMP]
- T cell differentiation in thymus [IDA]
- Wnt signaling pathway [IDA, ISO]
- bone development [ISO]
- branching involved in ureteric bud morphogenesis [IGI]
- canonical Wnt signaling pathway [IDA, IGI, ISO]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [ISO]
- cell-cell signaling [IDA, TAS]
- central nervous system morphogenesis [IMP]
- cerebellum formation [IMP]
- diencephalon development [IGI]
- embryonic axis specification [IMP]
- forebrain anterior/posterior pattern specification [IGI]
- hematopoietic stem cell proliferation [IDA]
- hepatocyte differentiation [ISO]
- inner ear morphogenesis [IGI]
- metencephalon development [IMP]
- midbrain development [IMP]
- midbrain-hindbrain boundary development [IMP]
- midbrain-hindbrain boundary maturation during brain development [IMP]
- myoblast fusion [IDA, IGI]
- myotube differentiation [IGI]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of cell aging [ISO]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of cell-substrate adhesion [ISO]
- negative regulation of fat cell differentiation [IDA, IMP]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- neuron fate commitment [IMP]
- neuron fate determination [IMP]
- organ morphogenesis [TAS]
- organ regeneration [ISO]
- positive regulation of Notch signaling pathway [ISO]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of dermatome development [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of insulin-like growth factor receptor signaling pathway [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- signal transduction [TAS]
- signal transduction in response to DNA damage [ISO]
- spinal cord association neuron differentiation [IGI]
- ubiquitin-dependent SMAD protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.
The Drosophila segment polarity gene product Porcupine (Porc) was first identified as being necessary for processing Wingless (Wg), a Drosophila Wnt (Wnt) family member. Mouse and Xenopus homologs of porc (Mporc and Xporc) were identified and found to encode endoplasmic reticulum (ER) proteins with multiple transmembrane domains. In contrast with porc, four different types of Mporc and Xporc mRNA (A-D) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID