PORCN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WNT3
Gene Ontology Biological Process
- Spemann organizer formation at the anterior end of the primitive streak [IMP]
- anatomical structure formation involved in morphogenesis [IMP]
- anterior/posterior axis specification [IMP]
- anterior/posterior pattern specification [IMP]
- axon guidance [IDA]
- canonical Wnt signaling pathway [IGI, ISO]
- canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [ISO]
- canonical Wnt signaling pathway involved in osteoblast differentiation [ISO]
- cell morphogenesis [ISO]
- cell-cell signaling [TAS]
- dorsal/ventral axis specification [IMP]
- embryonic forelimb morphogenesis [IMP]
- embryonic hindlimb morphogenesis [IMP]
- gamete generation [IGI]
- head morphogenesis [IGI]
- limb bud formation [ISO]
- limb development [IMP]
- mesoderm formation [IMP]
- negative regulation of axon extension involved in axon guidance [IDA]
- organ morphogenesis [TAS]
- positive regulation of collateral sprouting in absence of injury [IDA]
- positive regulation of gene expression [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.
The Drosophila segment polarity gene product Porcupine (Porc) was first identified as being necessary for processing Wingless (Wg), a Drosophila Wnt (Wnt) family member. Mouse and Xenopus homologs of porc (Mporc and Xporc) were identified and found to encode endoplasmic reticulum (ER) proteins with multiple transmembrane domains. In contrast with porc, four different types of Mporc and Xporc mRNA (A-D) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID