PORCN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WNT4
Gene Ontology Biological Process
- T cell differentiation in thymus [IDA]
- anatomical structure development [IGI]
- androgen biosynthetic process [ISO]
- branching involved in ureteric bud morphogenesis [IMP]
- branching morphogenesis of an epithelial tube [IGI]
- canonical Wnt signaling pathway [IDA, IGI, ISO]
- cell differentiation [IMP]
- cell fate commitment [IMP]
- cell-cell signaling [TAS]
- cellular response to starvation [IEP]
- embryonic epithelial tube formation [IDA]
- establishment of protein localization to plasma membrane [IMP, ISO]
- female gonad development [IMP]
- female sex determination [ISO, ISS]
- gamete generation [IGI]
- hormone metabolic process [IMP]
- immature T cell proliferation in thymus [IMP]
- kidney morphogenesis [IGI]
- male gonad development [IMP, ISO, ISS]
- mesenchymal to epithelial transition [IMP]
- mesonephric tubule development [IGI]
- mesonephros development [IMP]
- metanephric mesenchymal cell differentiation [NAS]
- metanephric nephron development [IMP]
- metanephric nephron morphogenesis [IMP]
- metanephric tubule formation [IMP]
- metanephros development [IMP, TAS]
- negative regulation of apoptotic signaling pathway [IGI]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell migration [IGI]
- negative regulation of fibroblast growth factor receptor signaling pathway [IGI]
- negative regulation of gene expression [IMP, ISO]
- negative regulation of male gonad development [ISO]
- negative regulation of steroid biosynthetic process [ISO]
- negative regulation of testicular blood vessel morphogenesis [ISO]
- negative regulation of testosterone biosynthetic process [IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO, ISS]
- negative regulation of wound healing [IGI]
- nephron development [IMP]
- neuron differentiation [IBA]
- non-canonical Wnt signaling pathway [IDA]
- non-canonical Wnt signaling pathway via MAPK cascade [ISO]
- oocyte development [IGI, IMP]
- paramesonephric duct development [IMP, ISO]
- positive regulation of Rho GTPase activity [IGI]
- positive regulation of aldosterone biosynthetic process [ISO]
- positive regulation of bone mineralization [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of collagen biosynthetic process [ISO]
- positive regulation of cortisol biosynthetic process [ISO]
- positive regulation of dermatome development [ISO, ISS]
- positive regulation of focal adhesion assembly [IGI]
- positive regulation of meiosis [IGI]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of stress fiber assembly [IGI]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- protein palmitoylation [ISO]
- regulation of cell-cell adhesion [IMP]
- renal vesicle formation [IMP]
- renal vesicle induction [IDA]
- sex differentiation [IMP]
- signal transduction [TAS]
- smooth muscle cell differentiation [IDA, IMP]
- somatotropin secreting cell differentiation [IMP]
- tertiary branching involved in mammary gland duct morphogenesis [IMP]
- thyroid-stimulating hormone-secreting cell differentiation [IMP]
- tube morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.
The Drosophila segment polarity gene product Porcupine (Porc) was first identified as being necessary for processing Wingless (Wg), a Drosophila Wnt (Wnt) family member. Mouse and Xenopus homologs of porc (Mporc and Xporc) were identified and found to encode endoplasmic reticulum (ER) proteins with multiple transmembrane domains. In contrast with porc, four different types of Mporc and Xporc mRNA (A-D) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID