PORCN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WNT7A
Gene Ontology Biological Process
- Wnt signaling pathway involved in wound healing, spreading of epidermal cells [ISO]
- angiogenesis [IGI]
- asymmetric protein localization [IDA]
- canonical Wnt signaling pathway [IGI, ISO]
- cartilage condensation [ISO]
- cartilage development [IDA]
- cell fate commitment [IBA]
- cell proliferation in forebrain [ISO]
- cell-cell signaling [TAS]
- central nervous system vasculogenesis [IGI]
- cerebellar granule cell differentiation [IDA]
- chondrocyte differentiation [ISO]
- dorsal/ventral pattern formation [IMP]
- embryonic axis specification [ISO]
- embryonic digit morphogenesis [ISO]
- embryonic forelimb morphogenesis [IGI, IMP, ISO]
- embryonic hindlimb morphogenesis [IGI, ISO]
- embryonic limb morphogenesis [IGI]
- establishment of cell polarity [IDA]
- forelimb morphogenesis [IMP]
- hindlimb morphogenesis [IMP]
- limb development [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of neurogenesis [ISO]
- neurotransmitter secretion [IGI]
- non-canonical Wnt signaling pathway [IGI]
- organ morphogenesis [TAS]
- oviduct development [IMP]
- palate development [ISO]
- positive regulation of JNK cascade [IBA, ISO]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell proliferation [ISO]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of epithelial cell proliferation involved in wound healing [ISO]
- positive regulation of gene expression [IDA]
- positive regulation of receptor activity [ISO]
- positive regulation of synapse assembly [IDA, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of axon diameter [IDA]
- regulation of axonogenesis [IDA]
- regulation of cell proliferation [IMP]
- reproductive structure development [IMP]
- response to estrogen [IMP]
- signal transduction [TAS]
- skeletal muscle satellite cell activation [IDA]
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [IDA]
- skeletal system morphogenesis [IMP]
- skin morphogenesis [IMP]
- somatic stem cell division [IDA]
- somatic stem cell maintenance [IMP]
- stem cell development [ISO]
- synapse organization [IGI, IMP]
- uterus development [IMP]
- uterus morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.
The Drosophila segment polarity gene product Porcupine (Porc) was first identified as being necessary for processing Wingless (Wg), a Drosophila Wnt (Wnt) family member. Mouse and Xenopus homologs of porc (Mporc and Xporc) were identified and found to encode endoplasmic reticulum (ER) proteins with multiple transmembrane domains. In contrast with porc, four different types of Mporc and Xporc mRNA (A-D) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID