PORCN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WNT7B
Gene Ontology Biological Process
- Wnt signaling pathway [IGI, IMP]
- activation of JUN kinase activity [ISO]
- anatomical structure regression [IMP]
- angiogenesis [IGI, IMP]
- apoptotic process involved in patterning of blood vessels [IMP]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- cell fate commitment [IBA]
- cell proliferation in forebrain [IDA]
- cellular metabolic process [IMP]
- central nervous system vasculogenesis [IGI]
- chorio-allantoic fusion [IMP]
- developmental growth involved in morphogenesis [IMP]
- embryonic organ development [IMP]
- embryonic placenta morphogenesis [IMP]
- establishment or maintenance of polarity of embryonic epithelium [IMP]
- homeostatic process [IMP]
- in utero embryonic development [IMP]
- inner medullary collecting duct development [IMP]
- lobar bronchus development [IMP]
- lung development [IMP]
- lung epithelium development [IMP]
- lung morphogenesis [IMP]
- lung-associated mesenchyme development [IMP]
- metanephric collecting duct development [IMP]
- metanephric epithelium development [IMP]
- metanephric loop of Henle development [IMP]
- metanephros morphogenesis [IMP]
- negative regulation of neurogenesis [IDA]
- negative regulation of smoothened signaling pathway [IMP]
- neuron differentiation [IBA]
- neuron projection development [ISO]
- neuron projection morphogenesis [ISO]
- odontogenesis of dentin-containing tooth [IMP]
- outer medullary collecting duct development [IMP]
- oxygen homeostasis [IMP]
- positive regulation of JNK cascade [IBA, ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of receptor activity [IC]
- regulation of cell projection size [ISO]
- renal inner medulla development [IMP]
- renal outer medulla development [IMP]
- signal transduction [IC]
- smooth muscle cell differentiation [IMP]
- stem cell development [IDA]
- synapse organization [IGI]
- trachea cartilage morphogenesis [IMP]
- vasculature development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.
The Drosophila segment polarity gene product Porcupine (Porc) was first identified as being necessary for processing Wingless (Wg), a Drosophila Wnt (Wnt) family member. Mouse and Xenopus homologs of porc (Mporc and Xporc) were identified and found to encode endoplasmic reticulum (ER) proteins with multiple transmembrane domains. In contrast with porc, four different types of Mporc and Xporc mRNA (A-D) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID