BAIT
SFRP2
AI851596, Sdf5
secreted frizzled-related protein 2
GO Process (60)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IGI]
- anterior/posterior pattern specification [IGI]
- apoptotic process [IMP]
- bone morphogenesis [IMP]
- cardiac left ventricle morphogenesis [ISO]
- cartilage development [IMP]
- cellular response to X-ray [IDA]
- cellular response to extracellular stimulus [IDA]
- chondrocyte development [IMP]
- collagen fibril organization [IMP]
- convergent extension involved in axis elongation [IGI]
- development of primary male sexual characteristics [IGI]
- digestive tract morphogenesis [IGI]
- embryonic digit morphogenesis [IMP]
- hematopoietic stem cell proliferation [IDA]
- male gonad development [IGI]
- negative regulation of BMP signaling pathway [IDA, IGI]
- negative regulation of JUN kinase activity [IGI]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, ISO]
- negative regulation of cardiac muscle cell apoptotic process [IDA]
- negative regulation of cell growth [ISO]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of dermatome development [IDA]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of mesodermal cell fate specification [IGI]
- negative regulation of peptidyl-tyrosine phosphorylation [IDA]
- negative regulation of planar cell polarity pathway involved in axis elongation [IGI]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [IGI]
- neural tube development [IGI]
- outflow tract morphogenesis [ISO]
- patterning of blood vessels [IDA]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of angiogenesis [IDA]
- positive regulation of apoptotic process [ISO]
- positive regulation of canonical Wnt signaling pathway [IDA, IGI]
- positive regulation of catenin import into nucleus [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of endopeptidase activity [IDA]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of osteoblast differentiation [IGI]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of receptor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- post-anal tail morphogenesis [IMP]
- regulation of Wnt signaling pathway [IDA]
- regulation of apoptotic process [IMP]
- regulation of cell proliferation [IMP]
- regulation of establishment of planar polarity [IGI]
- regulation of stem cell division [IDA]
- response to drug [IDA]
- signal transduction [IDA]
- somitogenesis [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BMP1
Pcp, Tld
bone morphogenetic protein 1
GO Process (2)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction.
Secreted Frizzled-related proteins (sFRPs) have emerged as key regulators of a wide range of developmental and disease processes. Most of the known functions of mammalian sFRPs have been attributed to their ability to antagonize Wnt signalling. Recently however, Xenopus laevis and zebrafish sFRP, Sizzled, was shown to function as an antagonist of Chordin processing by Tolloid-like metalloproteinases. This has led ... [more]
Nat. Cell Biol. Jan. 01, 2009; 11(1);46-55 [Pubmed: 19079247]
Throughput
- Low Throughput
Curated By
- BioGRID