AI851596, Sdf5
secreted frizzled-related protein 2
GO Process (60)
GO Function (5)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Mus musculus


Pcp, Tld
bone morphogenetic protein 1
GO Process (2)
GO Function (3)
GO Component (2)
Mus musculus

Reconstituted Complex

An interaction is detected between purified proteins in vitro.


Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction.

Kobayashi K, Luo M, Zhang Y, Wilkes DC, Ge G, Grieskamp T, Yamada C, Liu TC, Huang G, Basson CT, Kispert A, Greenspan DS, Sato TN

Secreted Frizzled-related proteins (sFRPs) have emerged as key regulators of a wide range of developmental and disease processes. Most of the known functions of mammalian sFRPs have been attributed to their ability to antagonize Wnt signalling. Recently however, Xenopus laevis and zebrafish sFRP, Sizzled, was shown to function as an antagonist of Chordin processing by Tolloid-like metalloproteinases. This has led ... [more]

Nat. Cell Biol. Jan. 01, 2009; 11(1);46-55 [Pubmed: 19079247]


  • Low Throughput

Curated By

  • BioGRID