POM1
Gene Ontology Biological Process
- actin filament bundle distribution [TAS]
- activation of bipolar cell growth [IMP]
- cell morphogenesis involved in conjugation with cellular fusion [IMP]
- cellular protein localization [IMP]
- establishment of mitotic actomyosin contractile ring localization [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IGI, IMP]
- negative regulation of establishment of actomyosin contractile ring localization [TAS]
- protein localization to medial cortex [IMP]
- regulation of cell size [IGI]
- regulation of establishment or maintenance of cell polarity regulating cell shape [IMP]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PMK1
Gene Ontology Biological Process
- MAPK cascade [IDA]
- MAPK cascade involved in cell wall organization or biogenesis [IDA, IMP]
- cellular sodium ion homeostasis [ISS]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of calcium ion transport into cytosol [IMP]
- positive regulation of calcium-mediated signaling [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [EXP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
An epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces pombe, by systematically measuring the phenotypes associated with pairs of mutations. This high-density, quantitative genetic interaction map focused on various aspects of chromosome function, including transcription regulation and DNA repair/replication. The E-MAP uncovered a previously unidentified component of the RNA interference (RNAi) machinery (rsh1) and linked the RNAi pathway ... [more]
Quantitative Score
- -2.6495 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score > 2.0 for positive interactions (epistatic or suppressor interactions) and S score < -2.5 for negative interactions (synthetic sick/lethal interactions).
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
POM1 PMK1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.7411 | BioGRID | 787113 | |
PMK1 POM1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.7411 | BioGRID | 783307 | |
POM1 PMK1 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 435332 |
Curated By
- BioGRID