KDM4B
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ESR1
Gene Ontology Biological Process
- Sertoli cell proliferation [ISO]
- androgen metabolic process [IMP]
- antral ovarian follicle growth [IMP]
- cell growth [NAS]
- cellular response to estradiol stimulus [ISO]
- cellular response to estrogen stimulus [IMP]
- epithelial cell development [IMP]
- epithelial cell proliferation involved in mammary gland duct elongation [IMP]
- intracellular estrogen receptor signaling pathway [ISO]
- intracellular receptor signaling pathway [IDA]
- intracellular steroid hormone receptor signaling pathway [ISO]
- male gonad development [IMP]
- mammary gland alveolus development [IMP]
- mammary gland branching involved in pregnancy [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of glucose import [ISO]
- negative regulation of mitosis [NAS]
- negative regulation of neuron death [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of triglyceride metabolic process [ISO]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of epidermal growth factor receptor signaling pathway [ISO]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of phospholipase C activity [ISO]
- positive regulation of retinoic acid receptor signaling pathway [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [IMP]
- prostate epithelial cord elongation [IMP]
- regulation of apoptotic process [IMP]
- regulation of branching involved in prostate gland morphogenesis [IMP]
- regulation of neuron apoptotic process [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- response to estradiol [ISO]
- response to estrogen [ISO]
- steroid hormone mediated signaling pathway [ISO]
- transcription from RNA polymerase II promoter [IDA]
- uterus development [IGI]
- vagina development [IGI]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- beta-catenin binding [ISO]
- chromatin binding [IDA, ISO]
- core promoter sequence-specific DNA binding [ISO]
- enzyme binding [ISO]
- estrogen receptor activity [ISO]
- estrogen response element binding [ISO]
- estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- hormone binding [ISO]
- identical protein binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein complex binding [ISO]
- steroid binding [ISO]
- steroid hormone receptor activity [ISO]
- transcription factor binding [IPI, ISO]
- type 1 metabotropic glutamate receptor binding [ISO]
- DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- beta-catenin binding [ISO]
- chromatin binding [IDA, ISO]
- core promoter sequence-specific DNA binding [ISO]
- enzyme binding [ISO]
- estrogen receptor activity [ISO]
- estrogen response element binding [ISO]
- estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- hormone binding [ISO]
- identical protein binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein complex binding [ISO]
- steroid binding [ISO]
- steroid hormone receptor activity [ISO]
- transcription factor binding [IPI, ISO]
- type 1 metabotropic glutamate receptor binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Histone Demethylase JMJD2B Functions as a Co-Factor of Estrogen Receptor in Breast Cancer Proliferation and Mammary Gland Development.
Estrogen is a key regulator of normal function of female reproductive system and plays a pivotal role in the development and progression of breast cancer. Here, we demonstrate that JMJD2B (also known as KDM4B) constitutes a key component of the estrogen signaling pathway. JMJD2B is expressed in a high proportion of human breast tumors, and that expression levels significantly correlate ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ESR1 KDM4B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID