ATRX
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA damage response, signal transduction by p53 class mediator [IMP]
- DNA replication-independent nucleosome assembly [ISO]
- Sertoli cell development [IMP]
- cellular response to hydroxyurea [IMP]
- chromatin remodeling [ISO]
- forebrain development [IMP]
- negative regulation of telomeric RNA transcription from RNA pol II promoter [IMP]
- nucleosome assembly [ISO]
- positive regulation of nuclear cell cycle DNA replication [IMP]
- positive regulation of telomere maintenance [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- replication fork processing [IMP]
- seminiferous tubule development [IMP]
- spermatogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AR
Gene Ontology Biological Process
- Leydig cell differentiation [IMP]
- activation of prostate induction by androgen receptor signaling pathway [IMP]
- androgen receptor signaling pathway [IDA, ISO]
- cellular process [IDA]
- epithelial cell differentiation involved in prostate gland development [IMP]
- epithelial cell morphogenesis [IGI]
- fertilization [IMP]
- in utero embryonic development [IMP]
- intracellular receptor signaling pathway [ISO]
- lateral sprouting involved in mammary gland duct morphogenesis [IMP]
- male genitalia morphogenesis [IMP]
- male gonad development [IGI, IMP]
- male sex differentiation [ISO]
- male somatic sex determination [IMP]
- mammary gland alveolus development [IMP]
- morphogenesis of an epithelial fold [IMP]
- multicellular organism growth [IGI]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of integrin biosynthetic process [ISO]
- organ formation [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of insulin-like growth factor receptor signaling pathway [IMP]
- positive regulation of integrin biosynthetic process [ISO]
- positive regulation of intracellular estrogen receptor signaling pathway [IMP]
- positive regulation of phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- prostate gland epithelium morphogenesis [IMP]
- prostate gland growth [IMP]
- protein oligomerization [ISO]
- regulation of catalytic activity [IMP]
- regulation of developmental growth [IMP]
- regulation of establishment of protein localization to plasma membrane [ISO]
- regulation of gene expression [IMP]
- regulation of prostatic bud formation [IGI]
- regulation of systemic arterial blood pressure [IGI]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IDA]
- reproductive structure development [IMP]
- reproductive system development [IGI]
- seminiferous tubule development [IGI, IMP]
- single fertilization [IGI]
- spermatogenesis [IMP]
- steroid hormone mediated signaling pathway [ISO]
- tertiary branching involved in mammary gland duct morphogenesis [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transcription, DNA-templated [ISO]
Gene Ontology Molecular Function- POU domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription factor binding [ISO]
- androgen binding [ISO]
- androgen receptor activity [IDA, ISO]
- androgen receptor binding [ISO]
- beta-catenin binding [ISO]
- chromatin binding [ISO]
- enzyme binding [IPI, ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- receptor binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- POU domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription factor binding [ISO]
- androgen binding [ISO]
- androgen receptor activity [IDA, ISO]
- androgen receptor binding [ISO]
- beta-catenin binding [ISO]
- chromatin binding [ISO]
- enzyme binding [IPI, ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- receptor binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome.
X-linked ATR-X (alpha thalassemia, mental retardation, X-linked) syndrome in males is characterized by mental retardation, facial dysmorphism, alpha thalassemia and urogenital abnormalities, including small testes. It is unclear how mutations in the chromatin-remodeling protein ATRX cause these highly specific clinical features, since ATRX is widely expressed during organ development. To investigate the mechanisms underlying the testicular defects observed in ATR-X ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AR ATRX | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID