EFNA5
Gene Ontology Biological Process
- apoptotic process [IDA]
- axon guidance [IBA]
- ephrin receptor signaling pathway [IDA]
- nervous system development [TAS]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- regulation of Rac GTPase activity [ISS]
- regulation of Rho GTPase activity [IDA]
- regulation of actin cytoskeleton organization [IDA]
- regulation of cell-cell adhesion [IDA]
- regulation of focal adhesion assembly [IDA]
- regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
- regulation of microtubule cytoskeleton organization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRIP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Coactivators PGC-1beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen.
PGC-1beta is a transcriptional coactivator that enhances strongly and in a hormone-dependent manner the activity of the estrogen receptor alpha (ERalpha) while having only weak effects on similar steroid hormone receptors, such as ERbeta or the glucocorticoid receptor. Notably, PGC-1beta enhances ERalpha transcriptional activity not only in response to agonist ligands, such as estradiol, but also to selective ER modulators, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID