NR5A2
Gene Ontology Biological Process
- bile acid metabolic process [IMP]
- cholesterol homeostasis [IMP]
- epithelial cell differentiation [IMP]
- intracellular receptor signaling pathway [ISO]
- pancreas morphogenesis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of viral genome replication [ISO]
- regulation of cell proliferation [IGI]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [ISO]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- double-stranded DNA binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- phospholipid binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- double-stranded DNA binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- phospholipid binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
NR1H4
Gene Ontology Biological Process
- bile acid metabolic process [IMP, ISO]
- cellular response to bile acid [IMP]
- cellular response to organonitrogen compound [IMP]
- intracellular bile acid receptor signaling pathway [ISO]
- intracellular receptor signaling pathway [IMP]
- negative regulation of bile acid biosynthetic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- nitrogen catabolite activation of transcription from RNA polymerase II promoter [IC]
- positive regulation of ammonia assimilation cycle [IMP]
- positive regulation of glutamate metabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- regulation of carbohydrate metabolic process [ISO]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of urea metabolic process [IMP]
- steroid hormone mediated signaling pathway [ISO]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- bile acid binding [IMP, ISO]
- bile acid receptor activity [ISO]
- chenodeoxycholic acid binding [ISO]
- double-stranded DNA binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IMP]
- peptide binding [ISO]
- receptor activity [ISO]
- retinoid X receptor binding [IDA]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IGI]
- steroid hormone receptor activity [ISO]
- DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- bile acid binding [IMP, ISO]
- bile acid receptor activity [ISO]
- chenodeoxycholic acid binding [ISO]
- double-stranded DNA binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IMP]
- peptide binding [ISO]
- receptor activity [ISO]
- retinoid X receptor binding [IDA]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IGI]
- steroid hormone receptor activity [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1.
We used mouse hepatic chromatin enriched with an FXR antibody and chromatin immunoprecipitation-sequencing (ChIP-seq) to evaluate FXR binding on a genome-wide scale. This identified 1656 FXR-binding sites and 10% were located within 2 kb of a transcription start site which is much higher than predicted by random occurrence. A motif search uncovered a canonical nuclear receptor IR-1 site, consistent with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID