PREY

HDAC2

HD2, RPD3, YAF1
histone deacetylase 2
GO Process (29)
GO Function (13)
GO Component (8)
Homo sapiens

Reconstituted Complex

An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.

Publication

HEF1-dependent Aurora A activation induces disassembly of the primary cilium.

Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA

The mammalian cilium protrudes from the apical/lumenal surface of polarized cells and acts as a sensor of environmental cues. Numerous developmental disorders and pathological conditions have been shown to arise from defects in cilia-associated signaling proteins. Despite mounting evidence that cilia are essential sites for coordination of cell signaling, little is known about the cellular mechanisms controlling their formation and ... [more]

Cell Jun. 29, 2007; 129(7);1351-63 [Pubmed: 17604723]

Throughput

  • Low Throughput

Curated By

  • BioGRID