BAG4
Gene Ontology Biological Process
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to tumor necrosis factor [ISO]
- negative regulation of mRNA modification [ISO]
- negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [IDA]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of fibroblast migration [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of stress fiber assembly [IMP]
- protein heterooligomerization [ISO]
- protein localization to plasma membrane [IDA]
- ruffle assembly [IMP]
Gene Ontology Molecular Function
HSPA1B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein.
The Bcl-2 oncoprotein is a potent inhibitor of apoptosis and is overexpressed in a variety of different malignancies. Bcl-2 function is regulated through heterodimerization with other members of the Bcl-2 protein family. In addition, several proteins that are not members of the Bcl-2 family can bind to Bcl-2, including BAG-1 protein. In this study, we screened for proteins that bind ... [more]
Throughput
- Low Throughput
Additional Notes
- Data only shown for Bag3.
Curated By
- BioGRID