BAIT

MLLT3

AF9, YEATS3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

Glioblastoma Project

GO Process (2)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

negative regulation of canonical Wnt signaling pathway [IDA, IGI]

positive regulation of Wnt signaling pathway, planar cell polarity pathway [IGI]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

extracellular vesicular exosome [IDA]

transcription elongation factor complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

EEF2

EEF-2, EF-2, EF2, SCA26

eukaryotic translation elongation factor 2

GO Process (6)

GO Function (4)

GO Component (8)

Gene Ontology Biological Process

cellular protein metabolic process [TAS]

gene expression [TAS]

positive regulation of gene expression [IGI]

positive regulation of translation [IGI]

translation [TAS]

translational elongation [TAS]

Gene Ontology Molecular Function

poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase binding [IPI]
translation activator activity [IGI]

Gene Ontology Cellular Component

aggresome [IDA]

cytoplasm [IDA]

extracellular vesicular exosome [IDA]

plasma membrane [IDA]

ribonucleoprotein complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Characterization of the DOT1L network: implications of diverse roles for DOT1L.

Park G, Gong Z, Chen J, Kim JE

Methylation of lysine 79 on histone H3 (H3K79) is mediated by a methyltransferase called Dot1-like protein (DOT1L). DOT1L is involved in the regulation of telomeric silencing, development, cell cycle checkpoint and transcription. However, the mechanisms by which DOT1L controls these unrelated and diverse functions are unknown. To gain greater insight into DOT1L-mediated functions, we have purified a DOT1L-containing complex using ... [more]

Protein J. Apr. 01, 2010; 29(3);213-23 [Pubmed: 20431927]

Throughput

Low Throughput

Curated By

BioGRID