BAIT
SRE1
SPBC19C2.09
sterol regulatory element binding protein, transcription factor Sre1
GO Process (11)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- SREBP signaling pathway [IMP]
- cellular response to hypoxia [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- oxygen metabolic process [IMP]
- positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of heme biosynthetic process [IEP]
- positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [IMP]
- regulation of transcription, start site selection [IEP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- protein binding [IPI]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- protein binding [IPI]
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
TSF1
SPBC800.07c
mitochondrial translation elongation factor EF-Ts Tsf1
GO Process (4)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Yeast SREBP Cleavage Activation Requires the Golgi Dsc E3 Ligase Complex.
Mammalian lipid homeostasis requires proteolytic activation of membrane-bound sterol regulatory element binding protein (SREBP) transcription factors through sequential action of the Golgi Site-1 and Site-2 proteases. Here we report that while SREBP function is conserved in fungi, fission yeast employs a different mechanism for SREBP cleavage. Using genetics and biochemistry, we identified four genes defective for SREBP cleavage, dsc1-4, encoding ... [more]
Mol. Cell Apr. 22, 2011; 42(2);160-71 [Pubmed: 21504829]
Quantitative Score
- -3.394507 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score >= 2.0 for positive interactions (epistatic or suppressor interactions) and S score <= -2.5 for negative interactions (synthetic sick/lethal interactions).
Curated By
- BioGRID