BAIT
THRA
AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1
thyroid hormone receptor, alpha
GO Process (8)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- gene expression [TAS]
- hormone-mediated signaling pathway [IDA]
- negative regulation of DNA-templated transcription, initiation [IDA]
- negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- TBP-class protein binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- thyroid hormone binding [IDA, IPI]
- thyroid hormone receptor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- TBP-class protein binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- thyroid hormone binding [IDA, IPI]
- thyroid hormone receptor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Homo sapiens
PREY
HSPA4
APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY
heat shock 70kDa protein 4
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity.
It is well documented that unliganded thyroid hormone receptor (TR) functions as a transcriptional repressor of specific cellular target genes by acting in concert with a corepressor complex harboring histone deacetylase (HDAC) activity. To fully explore the cofactors that interact with the transcriptionally repressive form of TR, we biochemically isolated a multiprotein complex that assembles on a TR.retinoid X receptor ... [more]
J. Biol. Chem. Mar. 30, 2007; 282(13);9312-22 [Pubmed: 17242407]
Throughput
- Low Throughput
Curated By
- BioGRID