BAIT
SSPN
DAGA5, KRAG, NSPN, SPN1, SPN2
sarcospan
GO Process (2)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
SUPT6
5131400N11Rik, AI132449, SPT6, Supt6h, mKIAA0162
suppressor of Ty 6
GO Process (6)
GO Function (3)
GO Component (0)
Gene Ontology Biological Process
- negative regulation of histone H3-K27 methylation [IMP, ISO]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP, ISO]
- regulation of isotype switching [IMP]
- regulation of mRNA export from nucleus [IMP]
- regulation of mRNA processing [IMP]
- regulation of muscle cell differentiation [IMP]
Gene Ontology Molecular Function
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export.
Spt6 promotes transcription elongation at many genes and functions as a histone H3 chaperone to alter chromatin structure during transcription. We show here that mammalian Spt6 binds Ser2-phosphorylated (Ser2P) RNA polymerase II (RNAPII) through a primitive SH2 domain, which recognizes phosphoserine rather than phosphotyrosine residues. Surprisingly, a point mutation in the Spt6 SH2 domain (R1358K) blocked binding to RNAPIIo without ... [more]
Genes Dev. Jan. 15, 2007; 21(2);160-74 [Pubmed: 17234882]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SUPT6 SSPN | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID