BAIT
UBE2I
5830467E05Rik, F830028O17Rik, UBC9, Ubce2i, Ubce9
ubiquitin-conjugating enzyme E2I
GO Process (10)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein sumoylation [IBA, ISO]
- protein ubiquitination [IBA, ISO]
- regulation of receptor activity [ISO]
Gene Ontology Molecular Function- HLH domain binding [IPI]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IBA, ISO]
- bHLH transcription factor binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- HLH domain binding [IPI]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IBA, ISO]
- bHLH transcription factor binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin-protein transferase activity [ISO]
Mus musculus
PREY
SOX2
Sox-2, lcc, ysb, AL606746.1
SRY (sex determining region Y)-box 2
GO Process (53)
GO Function (12)
GO Component (6)
Gene Ontology Biological Process
- adenohypophysis development [IMP]
- anatomical structure formation involved in morphogenesis [IMP]
- cell cycle arrest [ISO]
- cell fate commitment [IDA]
- cell fate specification [IMP]
- cerebral cortex development [IMP]
- detection of mechanical stimulus involved in equilibrioception [IMP]
- detection of mechanical stimulus involved in sensory perception of sound [IMP]
- diencephalon morphogenesis [IMP]
- embryonic organ development [IMP]
- endodermal cell fate specification [ISO]
- epithelial tube branching involved in lung morphogenesis [IDA]
- forebrain neuron differentiation [IMP]
- inner ear morphogenesis [IMP]
- lens induction in camera-type eye [IGI]
- lung alveolus development [IDA]
- male genitalia development [IMP]
- negative regulation of Wnt signaling pathway [IGI]
- negative regulation of canonical Wnt signaling pathway [IDA, ISO]
- negative regulation of cell differentiation [IMP]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of neuron differentiation [IDA]
- negative regulation of osteoblast differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- neuron fate commitment [IMP]
- neuronal stem cell maintenance [IGI]
- olfactory placode formation [IGI]
- osteoblast differentiation [ISO]
- pigment biosynthetic process [IMP]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Notch signaling pathway [IDA]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell-cell adhesion [ISO]
- positive regulation of epithelial cell differentiation [IDA]
- positive regulation of neuroblast proliferation [IMP]
- positive regulation of neuron differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- regulation of gene expression [ISO]
- regulation of neurogenesis [IGI]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to growth factor [ISO]
- response to organic substance [IDA]
- response to retinoic acid [IDA]
- retina morphogenesis in camera-type eye [IMP]
- sensory perception of sound [IMP]
- somatic stem cell maintenance [ISO]
- stem cell differentiation [IDA]
- stem cell maintenance [IMP]
- tongue development [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, IGI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- miRNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
- DNA binding [IDA, IGI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- miRNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Biochemical Activity (Sumoylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Inhibition of DNA binding of Sox2 by the SUMO conjugation.
Sox2 is a member of the high mobility group (HMG) domain DNA-binding proteins for transcriptional control and chromatin architecture. The HMG domain of Sox2 binds the DNA to facilitate transactivation by the cooperative transcription factors such as Oct3/4. We report that mouse Sox2 is modified by SUMO at lysine 247. Substitution of the target lysine to arginine lost the sumoylation ... [more]
Biochem. Biophys. Res. Commun. Dec. 29, 2006; 351(4);920-6 [Pubmed: 17097055]
Throughput
- Low Throughput
Additional Notes
- E1: Sae1/Uba2
Curated By
- BioGRID