BAIT
HOXD13
Hox-4.8, spdh, RP23-313J15.6
homeobox D13
GO Process (16)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- anterior/posterior pattern specification [IMP]
- branch elongation of an epithelium [IMP]
- embryonic digit morphogenesis [IGI]
- embryonic hindgut morphogenesis [ISO]
- embryonic limb morphogenesis [IMP]
- gland morphogenesis [IMP]
- limb morphogenesis [IGI, IMP]
- male genitalia development [IMP]
- morphogenesis of an epithelial fold [IMP]
- pattern specification process [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [IGI]
- regulation of branching involved in prostate gland morphogenesis [IMP]
- regulation of cell proliferation [IMP]
- skeletal system development [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
Mus musculus
PREY
HAND2
AI225906, AI661148, Ehand2, Hed, Th2, Thing2, bHLHa26, dHAND
heart and neural crest derivatives expressed transcript 2
GO Process (38)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- adult heart development [IMP]
- apoptotic process involved in heart morphogenesis [IMP]
- cardiac neural crest cell development involved in outflow tract morphogenesis [IMP]
- cardiac neural crest cell migration involved in outflow tract morphogenesis [IMP]
- cardiac right ventricle formation [IMP]
- cartilage morphogenesis [IGI]
- cell proliferation involved in outflow tract morphogenesis [IMP]
- coronary artery morphogenesis [IMP]
- determination of heart left/right asymmetry [IMP]
- embryonic digit morphogenesis [IDA]
- heart development [IGI]
- heart looping [IMP]
- heart morphogenesis [IMP]
- in utero embryonic development [IMP]
- mesenchymal cell proliferation [IMP]
- mesenchyme development [IGI]
- negative regulation of DNA binding [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of cardiac muscle cell apoptotic process [IMP]
- negative regulation of osteoblast differentiation [IDA, IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- neural crest cell development [IMP]
- odontogenesis of dentin-containing tooth [IGI]
- palate development [IMP]
- peripheral nervous system neuron development [IDA]
- positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process [IMP]
- positive regulation of transcription regulatory region DNA binding [ISO]
- positive regulation of transcription, DNA-templated [IDA, IGI]
- regulation of secondary heart field cardioblast proliferation [IMP]
- regulation of transcription, DNA-templated [IDA]
- suckling behavior [IMP]
- sympathetic nervous system development [IDA]
- thymus development [IMP]
- tongue development [IMP]
- transcription from RNA polymerase II promoter [ISO]
- visceral serous pericardium development [IMP]
Gene Ontology Molecular Function- AT DNA binding [ISO]
- E-box binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- activating transcription factor binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IGI]
- transcription coactivator activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA]
- AT DNA binding [ISO]
- E-box binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- activating transcription factor binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IGI]
- transcription coactivator activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.
The polarization of nascent embryonic fields and the endowment of cells with organizer properties are key to initiation of vertebrate organogenesis. One such event is antero-posterior (AP) polarization of early limb buds and activation of morphogenetic Sonic Hedgehog (SHH) signaling in the posterior mesenchyme, which in turn promotes outgrowth and specifies the pentadactylous autopod. Inactivation of the Hand2 transcriptional regulator ... [more]
PLoS Genet. Apr. 01, 2010; 6(4);e1000901 [Pubmed: 20386744]
Throughput
- Low Throughput
Curated By
- BioGRID