SIX3
Gene Ontology Biological Process
- apoptotic process involved in development [ISS]
- brain development [TAS]
- cell proliferation in forebrain [ISS]
- epithelial cell maturation [ISS]
- eye development [IDA]
- forebrain dorsal/ventral pattern formation [IDA]
- lens development in camera-type eye [ISS]
- lens fiber cell apoptotic process [ISS]
- lens fiber cell differentiation [ISS]
- negative regulation of neuron differentiation [ISS]
- negative regulation of transcription, DNA-templated [IDA]
- neuroblast differentiation [ISS]
- neuroblast migration [ISS]
- optic vesicle morphogenesis [ISS]
- pituitary gland development [ISS]
- protein import into nucleus, translocation [ISS]
- proximal/distal axis specification [ISS]
- regulation of cell cycle phase transition [ISS]
- regulation of cell proliferation [ISS]
- regulation of neural precursor cell proliferation [ISS]
- regulation of neural retina development [ISS]
- regulation of neuroblast proliferation [ISS]
- telencephalon development [ISS]
- telencephalon regionalization [ISS]
- visual perception [TAS]
Gene Ontology Molecular Function
MTA1
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- double-strand break repair [IMP]
- entrainment of circadian clock by photoperiod [ISS]
- locomotor rhythm [ISS]
- negative regulation of nucleic acid-templated transcription [IMP]
- positive regulation of protein autoubiquitination [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- regulation of gene expression, epigenetic [IMP]
- regulation of inflammatory response [ISS]
- response to ionizing radiation [IDA]
- response to lipopolysaccharide [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression from Six3 corepressor.
Although Wnt1 downstream signaling components have been well studied and activated in human cancer, the pathways that regulate Wnt1 itself have not been explored in depth. Here, we provide gain-of-function, loss-of function, and molecular evidence supporting functional interactions between metastasis-associated protein 1 short-form (MTA1s), metastasis-associated protein 1 (MTA1), and Wnt1 signaling components during mammary gland development and tumorigenesis. Using multiple ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID