BAIT

QCR6

COR3, UCR6, ubiquinol--cytochrome-c reductase subunit 6, L000001546, YFR033C
Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space
Saccharomyces cerevisiae (S288c)
PREY

QCR7

COR4, CRO1, UCR7, ubiquinol--cytochrome-c reductase subunit 7, L000001547, YDR529C
Subunit 7 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b.

Zara V, Palmisano I, Conte L, Trumpower BL

The cytochrome bc1 complex of the yeast Saccharomyces cerevisiae is composed of 10 different subunits that are assembled as a symmetrical dimer in the inner mitochondrial membrane. Three of the subunits contain redox centers and participate in catalysis, whereas little is known about the function of the seven supernumerary subunits. To gain further insight into the function of the supernumerary ... [more]

Eur. J. Biochem. Mar. 01, 2004; 271(6);1209-18 [Pubmed: 15009199]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)
  • phenotype: fermentative growth (APO:0000308)

Additional Notes

  • double mutants show reduced growth on non-fermentable medium

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
QCR7 QCR6
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High6BioGRID
3621096
QCR6 QCR7
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1167BioGRID
537404

Curated By

  • BioGRID