BAIT
FAS1
tetrafunctional fatty acid synthase subunit FAS1, L000000601, YKL182W
Beta subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
GO Process (1)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [IDA, IMP]
- [acyl-carrier-protein] S-acetyltransferase activity [IDA, IMP]
- [acyl-carrier-protein] S-malonyltransferase activity [IDA, IMP]
- enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [IDA, IMP]
- fatty acid synthase activity [IMP]
- palmitoyltransferase activity [IDA, IMP]
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [IDA, IMP]
- [acyl-carrier-protein] S-acetyltransferase activity [IDA, IMP]
- [acyl-carrier-protein] S-malonyltransferase activity [IDA, IMP]
- enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [IDA, IMP]
- fatty acid synthase activity [IMP]
- palmitoyltransferase activity [IDA, IMP]
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
NRT1
THI71, YOR29-22, YOR071C
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; major transporter for 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine) uptake; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
An integrated approach to characterize genetic interaction networks in yeast metabolism.
Although experimental and theoretical efforts have been applied to globally map genetic interactions, we still do not understand how gene-gene interactions arise from the operation of biomolecular networks. To bridge the gap between empirical and computational studies, we i, quantitatively measured genetic interactions between ∼185,000 metabolic gene pairs in Saccharomyces cerevisiae, ii, superposed the data on a detailed systems biology ... [more]
Unknown May. 29, 2011; 0(0); [Pubmed: 21623372]
Quantitative Score
- -0.0802 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- cut-off value: interaction score > .08 and < -.08
Curated By
- BioGRID