BAIT
MSN4
stress-responsive transcriptional activator MSN4, L000001199, YKL062W
Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes, inducing gene expression; involved in diauxic shift
GO Process (21)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- age-dependent response to oxidative stress involved in chronological cell aging [IGI]
- cellular response to acidic pH [IMP]
- chromatin remodeling [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to acidic pH [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to cold [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to ethanol [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to freezing [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to heat stress [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to increased salt [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation [IGI]
- regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction [IGI]
- replicative cell aging [IGI]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
XBP1
L000004246, YIL101C
Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
GO Process (4)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Rewiring of genetic networks in response to DNA damage.
Although cellular behaviors are dynamic, the networks that govern these behaviors have been mapped primarily as static snapshots. Using an approach called differential epistasis mapping, we have discovered widespread changes in genetic interaction among yeast kinases, phosphatases, and transcription factors as the cell responds to DNA damage. Differential interactions uncover many gene functions that go undetected in static conditions. They ... [more]
Science Dec. 03, 2010; 330(6009);1385-9 [Pubmed: 21127252]
Quantitative Score
- -3.107053 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: resistance to chemicals (APO:0000087)
- phenotype: colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants in MMS-treated conditions. Genetic interactions were considered significant if they had an S score >=2.0 for positive interactions (epistatic or suppressor interactions) and S score <=2.5 for negative interactions (synthetic sick/lethal interactions).
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score >= 2.0 for positive interactions (epistatic or suppressor interactions) and S score <= -2.5 for negative interactions (synthetic sick/lethal interactions).
Curated By
- BioGRID