A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Fission yeast homologs of human XPC and CSB, rhp41 and rhp26, are involved in transcription-coupled repair of methyl methanesulfonate-induced DNA damage.

Kanamitsu K, Ikeda S

Methyl methanesulfonate (MMS) methylates nitrogen atoms in purines, and predominantly produces 7-methylguanine and 3-methyladenine (3-meA). Previously, we showed that base excision repair (BER) and nucleotide excision repair (NER) synergistically function to repair MMS-induced DNA damage in the fission yeast Schizosaccharomyces pombe. Here, we studied the roles of NER components in repair of 3-meA and BER intermediates such as the AP ... [more]

Genes Genet. Syst. Jun. 15, 2011; 86(2);83-91 [Pubmed: 21670547]

Throughput

Low Throughput

Ontology Terms

phenotype: resistance to chemicals (APO:0000087)

Additional Notes

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
NTH1 RAD51	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Roguev A (2008)	High	-14.9272	BioGRID	523082

Curated By

BioGRID

Interaction Summary

NTH1

Gene Ontology Biological Process

Gene Ontology Molecular Function

5-formyluracil DNA N-glycosylase activity [IDA]5-hydroxymethyluracil DNA N-glycosylase activity [IDA]8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [IDA]oxidized purine nucleobase lesion DNA N-glycosylase activity [IMP]oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [IMP]

Gene Ontology Cellular Component

RAD51