TBX2
Gene Ontology Biological Process
- aorta morphogenesis [ISS]
- atrioventricular canal development [ISS]
- cardiac muscle tissue development [ISS]
- cell aging [IDA]
- cellular senescence [IDA]
- embryonic camera-type eye morphogenesis [ISS]
- embryonic digit morphogenesis [ISS]
- endocardial cushion morphogenesis [ISS]
- muscle cell fate determination [ISS]
- negative regulation of cardiac chamber formation [ISS]
- negative regulation of heart looping [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- outflow tract morphogenesis [ISS]
- outflow tract septum morphogenesis [ISS]
- pharynx development [ISS]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of cell proliferation [IDA]
- regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [ISS]
Gene Ontology Molecular Function- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
EGR1
Gene Ontology Biological Process
- cellular response to cAMP [IBA]
- cellular response to gonadotropin stimulus [IBA]
- cellular response to heparin [ISS]
- cellular response to mycophenolic acid [ISS]
- cytokine-mediated signaling pathway [TAS]
- glomerular mesangial cell proliferation [ISS]
- interleukin-1-mediated signaling pathway [IMP]
- negative regulation of apoptotic process [IBA]
- positive regulation of glomerular metanephric mesangial cell proliferation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of long-term neuronal synaptic plasticity [IBA]
- regulation of protein sumoylation [IDA]
- skeletal muscle cell differentiation [IBA]
- transcription from RNA polymerase II promoter [IDA]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells.
T-box 2 (TBX2) is a transcription factor involved in mammary development and is known to be overexpressed in a subset of aggressive breast cancers. TBX2 has previously been shown to repress growth control genes such as p14(ARF) and p21(WAF1/cip1). In this study we show that TBX2 drives proliferation in breast cancer cells and this is abrogated after TBX2 small interfering ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TBX2 EGR1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 544061 |
Curated By
- BioGRID