BAIT
LMNA
Dhe
lamin A
GO Process (13)
GO Function (1)
GO Component (9)
Gene Ontology Biological Process
- establishment of cell polarity [NAS]
- establishment or maintenance of microtubule cytoskeleton polarity [IMP]
- muscle organ development [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- nuclear envelope organization [IGI]
- nucleus organization [IMP]
- positive regulation of cell aging [ISO]
- protein localization to nucleus [IMP]
- regulation of cell migration [IMP]
- regulation of protein localization to nucleus [IMP]
- sterol regulatory element binding protein import into nucleus [IMP]
- ventricular cardiac muscle cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SYNE2
6820443O06Rik, AW546258, D12Ertd777e, NUA, Nesp2g, mKIAA1011
spectrin repeat containing, nuclear envelope 2
GO Process (9)
GO Function (1)
GO Component (17)
Gene Ontology Biological Process
- centrosome localization [IMP, ISO]
- cytoskeletal anchoring at nuclear membrane [ISO]
- establishment or maintenance of cell polarity [IMP]
- fibroblast migration [IMP]
- nuclear envelope organization [IMP]
- nuclear migration [ISO]
- nuclear migration along microfilament [IMP]
- positive regulation of cell migration [IMP]
- protein localization to nucleus [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SUN-KASH complex [ISO]
- Z disc [IDA, ISO]
- aggresome [ISO]
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- intermediate filament cytoskeleton [ISO]
- lamellipodium membrane [ISO]
- mitochondrion [ISO]
- myofibril [IDA]
- nuclear envelope [IDA, IMP, ISO]
- nuclear lumen [ISO]
- nuclear membrane [IDA, ISO]
- nuclear outer membrane [IDA]
- nucleus [ISO]
- sarcoplasmic reticulum [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of differential protein interactors of lamin A and progerin.
The nuclear lamina is an interconnected meshwork of intermediate filament proteins underlying the nuclear envelope. The lamina is an important regulator of nuclear structural integrity as well as nuclear processes, including transcription, DNA replication and chromatin remodeling. The major components of the lamina are A- and B-type lamins. Mutations in lamins impair lamina functions and cause a set of highly ... [more]
Unknown Dec. 01, 2009; 1(6);513-525 [Pubmed: 21327095]
Throughput
- Low Throughput
Curated By
- BioGRID