BAIT
LMNA
Dhe
lamin A
GO Process (13)
GO Function (1)
GO Component (9)
Gene Ontology Biological Process
- establishment of cell polarity [NAS]
- establishment or maintenance of microtubule cytoskeleton polarity [IMP]
- muscle organ development [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- nuclear envelope organization [IGI]
- nucleus organization [IMP]
- positive regulation of cell aging [ISO]
- protein localization to nucleus [IMP]
- regulation of cell migration [IMP]
- regulation of protein localization to nucleus [IMP]
- sterol regulatory element binding protein import into nucleus [IMP]
- ventricular cardiac muscle cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAB7
Rab7a
RAB7, member RAS oncogene family
GO Process (14)
GO Function (5)
GO Component (15)
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA]
- bone resorption [ISO]
- early endosome to late endosome transport [ISO]
- endosome to lysosome transport [IBA, ISO]
- epidermal growth factor catabolic process [ISO]
- intracellular protein transport [TAS]
- phagosome acidification [ISO]
- phagosome-lysosome fusion [IBA, ISO]
- positive regulation of exosomal secretion [ISO]
- protein targeting to lysosome [ISO]
- protein to membrane docking [ISO]
- regulation of autophagic vacuole assembly [ISO]
- retrograde transport, endosome to Golgi [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- alveolar lamellar body [ISO]
- cell [TAS]
- cytoplasm [IDA]
- cytoplasmic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [TAS]
- intracellular membrane-bounded organelle [ISO]
- late endosome [IDA, ISO]
- lysosome [IBA, ISO]
- phagocytic vesicle [IBA, ISO]
- pre-autophagosomal structure membrane [IDA]
- retromer complex [ISO]
- terminal bouton [ISO]
- vacuolar membrane [IBA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of differential protein interactors of lamin A and progerin.
The nuclear lamina is an interconnected meshwork of intermediate filament proteins underlying the nuclear envelope. The lamina is an important regulator of nuclear structural integrity as well as nuclear processes, including transcription, DNA replication and chromatin remodeling. The major components of the lamina are A- and B-type lamins. Mutations in lamins impair lamina functions and cause a set of highly ... [more]
Unknown Dec. 01, 2009; 1(6);513-525 [Pubmed: 21327095]
Throughput
- Low Throughput
Curated By
- BioGRID