BAIT

CHAF1A

CAF-1, CAF1, CAF1B, CAF1P150, P150
chromatin assembly factor 1, subunit A (p150)
Fanconi Anemia Project
Homo sapiens
PREY

EIF3C

EIF3CL, EIF3S8, eIF3-p110
eukaryotic translation initiation factor 3, subunit C
GO Process (4)
GO Function (3)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

An analysis of CAF-1-interacting proteins reveals dynamic and direct interactions with the KU complex and 14-3-3 proteins.

Hoek M, Myers MP, Stillman B

CAF-1 is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork. Depletion of CAF-1 from various cell lines causes replication fork arrest, activation of the intra-S phase checkpoint, and global defects in chromatin structure. CAF-1 is also involved in coordinating inheritance of states of gene expression and in chromatin assembly ... [more]

J. Biol. Chem. Mar. 25, 2011; 286(12);10876-87 [Pubmed: 21209461]

Throughput

  • Low Throughput

Curated By

  • BioGRID