SUP35
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BUG1
Gene Ontology Biological Process
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Prion formation and polyglutamine aggregation are controlled by two classes of genes.
Prions are self-perpetuating aggregated proteins that are not limited to mammalian systems but also exist in lower eukaryotes including yeast. While much work has focused around chaperones involved in prion maintenance, including Hsp104, little is known about factors involved in the appearance of prions. De novo appearance of the [PSI(+)] prion, which is the aggregated form of the Sup35 protein, ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: prion formation (APO:0000276)
Additional Notes
- deletion rescues the induction of the prion phenotype in a Sup35 mutant
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
BUG1 SUP35 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1234 | BioGRID | 2429088 | |
SUP35 BUG1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 544988 |
Curated By
- BioGRID