BAIT
ARK1
SPCC330.16, aim1, SPCC320.12c, SPCC320.13c
aurora-B kinase Ark1
GO Process (7)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- histone H3-S10 phosphorylation involved in chromosome condensation [IDA]
- mitotic cytokinesis [IGI, IMP]
- mitotic sister chromatid segregation [IGI, IMP]
- mitotic spindle assembly checkpoint [IMP]
- protein localization to kinetochore [IMP]
- protein localization to nucleolar rDNA repeats [IMP]
- sister chromatid biorientation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
SWI3
SPBC30D10.04
replication fork protection complex subunit Swi3
GO Process (4)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Kinases of the Aurora family are essential for the proper execution of mitosis in eukaryotes, and Aurora inhibitors are in clinical trials as anticancer drugs. We applied site-specific quantitative phosphoproteomics in conjunction with chemical inhibition of Aurora to identify mitotic Aurora substrates in fission yeast on a proteome-wide scale. We detected 8000 phosphorylation events, of which we assigned almost 6000 ... [more]
Sci Signal Jun. 30, 2011; 4(179);rs6 [Pubmed: 21712547]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- The temperature-sensitive ark1-T8 allele was used in the experiment.
Curated By
- BioGRID