RAD54
Gene Ontology Biological Process
- DNA geometric change [IDA]
- chromatin remodeling [IDA]
- double-strand break repair via single-strand annealing [IMP]
- double-strand break repair via synthesis-dependent strand annealing [TAS]
- heteroduplex formation [IDA]
- positive regulation of endodeoxyribonuclease activity [IDA]
- telomere maintenance via recombination [IMP]
Gene Ontology Molecular Function
LCD1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The Ddc2/ATRIP checkpoint protein monitors meiotic recombination intermediates.
During meiosis, accurate segregation of intact chromosomes is essential for generating healthy gametes. Defects in recombination and/or chromosome synapsis activate the pachytene checkpoint, which delays meiotic cell cycle progression to avoid aberrant chromosome segregation and formation of defective gametes. Here, we characterize the role of the conserved DNA damage checkpoint protein Ddc2/ATRIP in this meiotic surveillance mechanism. We show that ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: sporulation (APO:0000041)
- phenotype: inviable (APO:0000112)
Additional Notes
- deletion of ddc2 results in inviable spores in a rad54/dmc1 mutant background
- genetic complex
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAD54 LCD1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 545186 |
Curated By
- BioGRID