BAIT

MORF4L2

MORFL2, MRGX, RP5-1055C14.2
mortality factor 4 like 2
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

RBP2

CRABP-II, CRBP2, CRBPII, RBPC2
retinol binding protein 2, cellular
GO Process (4)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.

Hayakawa T, Zhang F, Hayakawa N, Ohtani Y, Shinmyozu K, Nakayama J, Andreassen PR

PALB2 physically and functionally connects the proteins encoded by the BRCA1 and BRCA2 breast and ovarian cancer genes into a DNA-damage-response network. However, it remains unclear how these proteins associate with chromatin that contains damaged DNA. We show here that PALB2 binds directly to a conserved chromodomain protein, MRG15, which is a component of histone acetyltransferase-deacetylase complexes. This interaction was ... [more]

J. Cell. Sci. Apr. 01, 2010; 123(0);1124-30 [Pubmed: 20332121]

Throughput

  • Low Throughput

Curated By

  • BioGRID