SMYD2
Gene Ontology Biological Process
- histone H3-K36 methylation [IDA]
- histone methylation [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- peptidyl-lysine dimethylation [IDA]
- peptidyl-lysine monomethylation [ISO]
- regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
Gene Ontology Molecular Function
HELZ
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cardiac deletion of Smyd2 is dispensable for mouse heart development.
Chromatin modifying enzymes play a critical role in cardiac differentiation. Previously, it has been shown that the targeted deletion of the histone methyltransferase, Smyd1, the founding member of the SET and MYND domain containing (Smyd) family, interferes with cardiomyocyte maturation and proper formation of the right heart ventricle. The highly related paralogue, Smyd2 is a histone 3 lysine 4- and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HELZ SMYD2 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.943 | BioGRID | 2686505 |
Curated By
- BioGRID