An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.

Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N, Mueller JM, Greschik H, Kirfel J, Ji S, Kunowska N, Beisenherz-Huss C, Guenther T, Buettner R, Schuele R

Demethylation at distinct lysine residues in histone H3 by lysine-specific demethylase 1 (LSD1) causes either gene repression or activation. As a component of co-repressor complexes, LSD1 contributes to target gene repression by removing mono- and dimethyl marks from lysine 4 of histone H3 (H3K4). In contrast, during androgen receptor (AR)-activated gene expression, LSD1 removes mono- and dimethyl marks from lysine ... [more]

Nature Apr. 01, 2010; 464(7289);792-6 [Pubmed: 20228790]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

PRKCB

Gene Ontology Biological Process

Gene Ontology Molecular Function

androgen receptor binding [IDA]chromatin binding [IDA]histone binding [IDA]histone kinase activity (H3-T6 specific) [IDA]ligand-dependent nuclear receptor transcription coactivator activity [IMP]protein binding [IPI]protein kinase C binding [IPI]protein serine/threonine kinase activity [TAS]

Gene Ontology Cellular Component

HIST1H3A