FADD
Gene Ontology Biological Process
- T cell differentiation [TAS]
- T cell differentiation in thymus [IMP]
- T cell homeostasis [IMP]
- TRAIL-activated apoptotic signaling pathway [ISO]
- activation of cysteine-type endopeptidase activity [ISO]
- apoptotic process [ISO]
- apoptotic signaling pathway [ISO]
- cardiac muscle tissue development [TAS]
- defense response to virus [ISO]
- extrinsic apoptotic signaling pathway [IDA, ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- innate immune response [TAS]
- lymph node development [IGI]
- motor neuron apoptotic process [IMP]
- necroptotic signaling pathway [ISO]
- negative regulation of activation-induced cell death of T cells [IMP]
- negative regulation of necroptotic process [IGI]
- positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [IMP]
- positive regulation of T cell mediated cytotoxicity [IMP]
- positive regulation of activated T cell proliferation [IMP]
- positive regulation of adaptive immune response [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IGI, ISO]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IGI]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of macrophage differentiation [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of type I interferon-mediated signaling pathway [ISO]
- protein heterooligomerization [ISO]
- spleen development [IGI]
- thymus development [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CASP8
Gene Ontology Biological Process
- TRAIL-activated apoptotic signaling pathway [ISO]
- activation of cysteine-type endopeptidase activity [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- angiogenesis [IMP]
- apoptotic process [IDA, ISO]
- apoptotic signaling pathway [IDA, ISO]
- cardiac muscle tissue development [TAS]
- execution phase of apoptosis [ISO]
- extrinsic apoptotic signaling pathway [IDA, IGI, ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- heart development [IMP]
- hepatocyte apoptotic process [IMP]
- macrophage differentiation [IMP, TAS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of necroptotic process [IGI]
- neural tube formation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IGI]
- positive regulation of macrophage differentiation [ISO]
- positive regulation of proteolysis [ISO]
- protein heterooligomerization [ISO]
- proteolysis [IGI, ISO]
- proteolysis involved in cellular protein catabolic process [ISO]
- regulation of apoptotic signaling pathway [IGI]
- regulation of thymocyte apoptotic process [IGI]
- response to ethanol [ISO]
- response to tumor necrosis factor [ISO]
Gene Ontology Molecular Function- cysteine-type endopeptidase activity [IDA, IGI, ISO]
- cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO]
- death effector domain binding [IBA, ISO]
- death receptor binding [ISO]
- endopeptidase activity [IDA, IMP]
- peptidase activity [IDA, IMP, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [IPI]
- scaffold protein binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- cysteine-type endopeptidase activity [IDA, IGI, ISO]
- cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO]
- death effector domain binding [IBA, ISO]
- death receptor binding [ISO]
- endopeptidase activity [IDA, IMP]
- peptidase activity [IDA, IMP, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [IPI]
- scaffold protein binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- CD95 death-inducing signaling complex [ISO]
- Noc1p-Noc2p complex [IMP]
- cell body [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- death-inducing signaling complex [ISO]
- membrane raft [ISO]
- microtubule organizing center [ISO]
- mitochondrion [IDA, ISO]
- neuron projection [ISO]
- nucleoplasm [ISO]
- nucleus [IDA]
- protein complex [ISO]
- ripoptosome [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.
The proinflammatory cytokine tumor necrosis factor (TNF) alpha signals both cell survival and death. The biological outcome of TNFalpha treatment is determined by the balance between NF-kappaB and Jun kinase (JNK) signaling; NF-kappaB promotes survival, whereas JNK enhances cell death. Critically, identity of a JNK substrate that promotes TNFalpha-induced apoptosis has been outstanding. Here we show that TNFalpha-mediated JNK activation ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FADD CASP8 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FADD CASP8 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FADD CASP8 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FADD CASP8 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FADD CASP8 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FADD CASP8 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID