NAB3
Gene Ontology Biological Process
Gene Ontology Molecular Function
SET1
Gene Ontology Biological Process
- ascospore formation [IMP]
- chromatin silencing at rDNA [TAS]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- histone H3-K4 methylation [IDA, IMP]
- peptidyl-lysine dimethylation [IMP, IPI]
- positive regulation of histone acetylation [IGI]
- regulation of transcription from RNA polymerase II promoter in response to stress [IGI, IMP]
- telomere maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway.
In Saccharomyces cerevisiae, the Nrd1-Nab3-Sen1 pathway mediates termination of snoRNAs and cryptic unstable transcripts (CUTs). Both Nrd1 and the Set1 histone H3K4 methyltransferase complex interact with the RNA polymerase II (Pol II) during early elongation, leading us to test whether these two processes are functionally linked. Deletion of SET1 exacerbates the growth rate and termination defects of nrd1 mutants. Set1 ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: rna accumulation (APO:0000224)
Additional Notes
- double mutants show increased read-through of snRNA
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SET1 NAB3 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1022 | BioGRID | 2427586 | |
| SET1 NAB3 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.2162 | BioGRID | 2437484 | |
| NAB3 SET1 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 2450655 | |
| NAB3 SET1 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 3022836 |
Curated By
- BioGRID