YKU70
Gene Ontology Biological Process
- chromatin assembly or disassembly [IDA]
- chromatin silencing [IDA, IMP]
- chromatin silencing at silent mating-type cassette [IGI, IMP]
- double-strand break repair via break-induced replication [IGI, IMP]
- double-strand break repair via homologous recombination [IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- mitochondrial double-strand break repair via homologous recombination [IMP]
- telomere maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDC13
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
SUMOylation regulates telomere length homeostasis by targeting Cdc13.
Telomere length homeostasis is an important aspect of telomere biology. Here, we show that SUMOylation limits telomere length and targets multiple telomere proteins in Saccharomyces cerevisiae. A main target is Cdc13, which both positively and negatively regulates telomerase and confers end protection. We demonstrate that Cdc13 SUMOylation restrains telomerase functions by promoting Cdc13 interaction with the telomerase inhibitor Stn1 without ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: telomere length (APO:0000144)
Additional Notes
- mutation of cdc13 suppresses the telomere length defects of ku mutants
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC13 YKU70 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 156137 | |
| CDC13 YKU70 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 657033 | |
| CDC13 YKU70 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | High | - | BioGRID | 327560 | |
| CDC13 YKU70 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 480994 | |
| YKU70 CDC13 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 159142 | |
| CDC13 YKU70 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 157750 | |
| YKU70 CDC13 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 158130 |
Curated By
- BioGRID