MAPK1
Gene Ontology Biological Process
- B cell receptor signaling pathway [ISO]
- ERBB signaling pathway [ISO]
- ERK1 and ERK2 cascade [ISO]
- MAPK cascade [IMP, ISO]
- MAPK import into nucleus [IDA]
- T cell receptor signaling pathway [ISO]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [ISO]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [ISO]
- cellular response to organic substance [IDA]
- cytosine metabolic process [ISO]
- intracellular signal transduction [IDA, TAS]
- labyrinthine layer blood vessel development [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO]
- mammary gland epithelial cell proliferation [ISO]
- negative regulation of cell differentiation [ISO]
- organ morphogenesis [ISO]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [ISO, ISS]
- positive regulation of cell migration [IEP]
- positive regulation of cell proliferation [IEP]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of transcription, DNA-templated [IEP]
- positive regulation of translation [IMP]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of protein stability [ISS]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO, ISS]
- response to estrogen [IDA]
- response to exogenous dsRNA [ISO]
- response to lipopolysaccharide [ISO]
- response to toxic substance [IDA]
- sensory perception of pain [IMP]
- signal transduction [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- MAP kinase activity [IDA, IMP, ISO, TAS]
- RNA polymerase II carboxy-terminal domain kinase activity [ISO]
- kinase activity [ISO, TAS]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatase binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IC, IDA, ISO, TAS]
- transcription factor binding [IPI]
- ATP binding [IDA]
- MAP kinase activity [IDA, IMP, ISO, TAS]
- RNA polymerase II carboxy-terminal domain kinase activity [ISO]
- kinase activity [ISO, TAS]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatase binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IC, IDA, ISO, TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- axon [IDA]
- caveola [TAS]
- cytoplasm [ISO, ISS]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- dendrite cytoplasm [IDA]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [ISO, TAS]
- mitotic spindle [ISS]
- nucleoplasm [IDA, ISO, TAS]
- nucleus [IDA, ISO, TAS]
- perikaryon [IDA]
- protein complex [IDA]
- pseudopodium [ISO]
MAPK3
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- DNA damage induced protein phosphorylation [ISO]
- MAPK cascade [IMP, ISO]
- MAPK import into nucleus [IDA]
- arachidonic acid metabolic process [IEP]
- cartilage development [ISO]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [ISO]
- cellular response to mechanical stimulus [ISO]
- interleukin-1-mediated signaling pathway [ISO]
- intracellular signal transduction [IDA, TAS]
- lipopolysaccharide-mediated signaling pathway [ISO]
- negative regulation of apolipoprotein binding [ISO]
- organ morphogenesis [ISO]
- peptidyl-serine phosphorylation [IMP]
- peptidyl-tyrosine autophosphorylation [ISO]
- phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of histone acetylation [ISO]
- positive regulation of histone phosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IEP]
- positive regulation of translation [IMP]
- protein complex assembly [IMP]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [ISO]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO, ISS]
- response to exogenous dsRNA [ISO]
- response to lipopolysaccharide [ISO]
- response to toxic substance [IDA]
- sensory perception of pain [ISO]
- transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- caveola [TAS]
- cytoplasm [ISO]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [TAS]
- nucleoplasm [IDA, ISO]
- nucleus [IDA, ISO, TAS]
- protein complex [IDA]
- pseudopodium [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
h3/Acidic calponin: an actin-binding protein that controls extracellular signal-regulated kinase 1/2 activity in nonmuscle cells.
Migration of fibroblasts is important in wound healing. Here, we demonstrate a role and a mechanism for h3/acidic calponin (aCaP, CNN3) in REF52.2 cell motility, a fibroblast line rich in actin filaments. We show that the actin-binding protein h3/acidic calponin associates with stress fibers in the absence of stimulation but is targeted to the cell cortex and podosome-like structures after ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAPK3 MAPK1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID