RET
Gene Ontology Biological Process
- MAPK cascade [ISO]
- Peyer's patch morphogenesis [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- cellular response to retinoic acid [ISO]
- embryonic epithelial tube formation [ISO]
- enteric nervous system development [ISO]
- innervation [IMP]
- membrane protein proteolysis [ISO]
- nervous system development [ISO]
- neural crest cell migration [ISO]
- neuron cell-cell adhesion [ISO]
- neuron differentiation [ISO]
- neuron maturation [ISO]
- positive regulation of cell adhesion mediated by integrin [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell size [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- positive regulation of metanephric glomerulus development [ISO]
- positive regulation of neuron maturation [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of axonogenesis [ISO]
- regulation of cell adhesion [ISO]
- response to drug [IEP]
- response to pain [ISO]
- retina development in camera-type eye [IEP]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
- ureter maturation [ISO]
- ureteric bud development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation.
The receptor tyrosine kinase (RTK) Ret is activated by the formation of a complex consisting of ligands such as glial cell line-derived neurotrophic factor (GDNF) and glycerophosphatidylinositol-anchored coreceptors termed GFRalphas. During activation, Ret translocates into lipid rafts, which is critical for functional responses to GDNF. We found that Ret was rapidly ubiquitinated and degraded in sympathetic neurons when activated with ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UBC RET | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID