NR1D1
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [IMP]
- circadian regulation of gene expression [ISS]
- circadian temperature homeostasis [ISS]
- gene expression [TAS]
- glycogen biosynthetic process [ISS]
- intracellular receptor signaling pathway [TAS]
- negative regulation of receptor biosynthetic process [IMP]
- negative regulation of toll-like receptor 4 signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of bile acid biosynthetic process [ISS]
- positive regulation of cholesterol homeostasis [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- proteasomal protein catabolic process [ISS]
- regulation of cholesterol homeostasis [ISS]
- regulation of circadian rhythm [ISS]
- regulation of fat cell differentiation [ISS]
- regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
- regulation of lipid metabolic process [ISS]
- regulation of type B pancreatic cell proliferation [ISS]
- response to leptin [ISS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter sequence-specific DNA binding [IDA]
- heme binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [TAS]
- protein binding [IPI]
- transcription corepressor activity [TAS]
- transcription corepressor binding [IDA, IMP]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter sequence-specific DNA binding [IDA]
- heme binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [TAS]
- protein binding [IPI]
- transcription corepressor activity [TAS]
- transcription corepressor binding [IDA, IMP]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
HUWE1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha.
The metazoan circadian clock mechanism involves cyclic transcriptional activation and repression by proteins whose degradation is highly regulated via the ubiquitin-proteasome pathway. The heme receptor Rev-erb alpha, a core negative component of the circadian network, controls circadian oscillation of several clock genes, including Bmal1 Rev-erb alpha protein degradation can be triggered by inhibitors of glycogen synthase kinase 3beta, such as ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NR1D1 HUWE1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID